Topirva XR 50 mg (Capsule (Extended Release))
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Topiramate |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Epilepsy
- Monotherapy
- Adjunctive therapy
- Migraine
- Prophylaxis
- Lennox Gastaut Syndrome
- Generalised tonic-clonic seizures
- Partial seizures
- Seizures associated with Lennox Gastaut Syndrome
Pharmacology
- Electrical discharge in brain
- Seizure interruption
- GABA receptor stimulation
- Glutamate receptor inhibition
- Neuronal excitability inhibition
- Blockage of voltage-dependent sodium channels
- Inhibition of carbonic anhydrase isozymes
Dosage & Administration
- Titration
- Initial target dose
- Maximum recommended daily dose
- Total daily dose
- Dose titration
- Nightly dosage
- Dosage increments
- Divided doses
- Daily dose range
- Prophylaxis dosage
Interaction
- Antiepileptic drugs interaction
- CNS Depressants caution
- Oral Contraceptives interaction
- Lithium levels monitoring
- Hydrochlorothiazide influence
- Metformin impact
- Pioglitazone monitoring
- Glibenclamide effect
- Nephrolithiasis risk increase
- Benzodiazepines interaction
- Valproic Acid association with hyperammonemia
Contraindications
- Hypersensitivity
Side Effects
- Nausea
- Abdominal pain
- Dyspepsia
- Diarrhoea
- Dry mouth
- Taste disturbance
- Weight loss
- Anorexia
- Paraesthesia
- Hypoaesthesia
- Headache
- Fatigue
- Dizziness
- Speech disorder
- Drowsiness
- Insomnia
- Impaired memory & concentration
- Anxiety
- Depression
- Visual disturbance
- Suicidal ideation
- Reduced sweetening
- Metabolic acidosis
- Alopecia
- Leucopenia
- Thrombocytopenia
- Serious skin reaction
Pregnancy & Lactation
- Pregnancy use caution
- Breastfeeding avoidance
Precautions & Warnings
- Gradual withdrawal
- Central nervous system-related adverse events
- Sedative effects
- Drowsiness likelihood
- Visual disturbances
- Not suitable for driving or operating machinery
Overdose Effects
- Severe metabolic acidosis
- Stomach emptying
- Activated charcoal adsorption
- Supportive treatment
- Haemodialysis effectiveness
- Hydration importance
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Temperature control
- Protection from light & moisture
- Keep out of children's reach