Topirva XR 25 mg (Capsule (Extended Release))
Unit Price: ৳ 7.00 (7 x 8: ৳ 392.00)
Strip Price: ৳ 56.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Topiramate |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Monotherapy for epilepsy in adults and children
- Adjunctive therapy for inadequately controlled epilepsy
- Prophylaxis of migraine headache in adults
Pharmacology
- Exerts actions on voltage-dependent sodium channels
- Stimulates GABA-A receptor activity
- Reduces glutamate activity at AMPA and kainate receptors
Dosage & Administration
- Recommended initial target dose for topiramate monotherapy in adults
- Recommended initial target dose range for topiramate monotherapy in children
- Usual total daily dose for adjunctive therapy in adults
- Recommended total daily dose for adjunctive therapy in children
- Titration guidelines
Interaction
- Effect on steady-state plasma concentrations of other antiepileptic drugs
- Caution when used with CNS depressants
- Increase in plasma clearance of the oestrogenic component with oral contraceptives
- Effects on lithium, hydrochlorothiazide, metformin, pioglitazone, glibenclamide, and others
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Nausea
- Abdominal pain
- Dry mouth
- Drowsiness
- Insomnia
- Anorexia
- Dizziness
- Headache
- Visual disturbance
- Metabolic acidosis
- Alopecia
- Leucopenia
- Thrombocytopenia
- Suicidal ideation
Pregnancy & Lactation
- Not to be used during pregnancy unless potential benefit outweighs potential risk
- Not to be used during breastfeeding
Precautions & Warnings
- Gradual withdrawal in patients with or without a history of seizures or epilepsy
- Potential sedative effects
- Potential visual disturbances/blurred vision
- Advice regarding driving and operating machinery
Overdose Effects
- Can result in severe metabolic acidosis
- Treatment with activated charcoal
- Effectiveness of haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children