Valex 500 mg/5 ml (IV Injection)

Indications

• Treatment of epilepsy
• Treatment of all types of seizures
• Prophylaxis of febrile convulsion
• Prophylaxis of post-traumatic epilepsy
• Treatment of bipolar disorder
• Prophylaxis of migraine

Composition

• Sodium Valproate tablet
• Sodium Valproate syrup
• Sodium Valproate controlled release 200 tablet
• Sodium Valproate controlled release 300 tablet
• Sodium Valproate controlled release 500 tablet
• Sodium Valproate injection

Pharmacology

• Antiepileptic activity
• Increase brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

• Oral administration
• Injectable administration
• Dosage for adults
• Dosage for children over 20 kg
• Dosage for children up to 20 kg
• Maintenance dosage for bipolar disorder
• Dosage for prophylaxis of migraine

Interaction

• Inhibition of drug metabolism
• Interaction with Phenobarbital
• Interaction with Phenytoin
• Interaction with Warfarin
• Interaction with Aspirin

Contraindications

• Hypersensitivity to Sodium Valproate
• Liver dysfunction
• Use restrictions during pregnancy
• Use restrictions in women of childbearing potential

Side Effects

• Anorexia
• Nausea
• Vomiting
• Sedation
• Ataxia
• Tremor
• Rash
• Alopecia
• Hepatic function effects
• Elevation of liver enzymes
• Fulminate hepatitis
• Acute pancreatitis
• Hyperammonemia

Pregnancy & Lactation

• Crosses the placenta
• Associated with neural tube defects
• Excreted in breast milk
• No risk to the child via breast milk

Precautions & Warnings

• Monitoring of liver functions
• No undue potential for bleeding
• Care in renal impairment
• Care in pregnancy
• Care in breast-feeding
• Elimination as ketone metabolite
• Avoidance of sudden withdrawal of therapy

Therapeutic Class

• Primary anti-epileptic drugs

Storage Conditions

• Do not store above 30°C
• Keep away from light
• Keep out of the reach of children

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