Voriderm 200 mg/vial (IV Injection)
200 mg vial: ৳ 2,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia and disseminated candidiasis
- Esophageal candidiasis treatment
- Treatment of serious infections caused by specific fungi
- Intolerance or refractory to other therapies
Pharmacology
- Triazole antifungal medication
- Inhibition of ergosterol synthesis
- Binding and inhibition of CYP450-dependent 14-alpha sterol demethylase
- Depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral administration with specific dosages based on body weight
- Loading and maintenance dose regimen for different conditions
- Injection dosages for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis
Interaction
- Adjust dosage and monitor for adverse reactions with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
- Potential increase in concentrations and activity of drugs that are substrates of CYP3A4, CYP2C9, and CYP2C19
- Increased maintenance oral and intravenous dosage with co-administration of specific drugs
Contraindications
- Hypersensitivity to Voriconazole or any other components
- Risk associated with co-administration of specific drugs
Side Effects
- Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
- Long term exposure requires careful assessment of benefit-risk balance
- Reported risk of squamous cell carcinoma of the skin with long-term treatment
Use in Special Populations
- Efficacy not established in children under 12 years of age
Overdose Effects
- No available data on overdose
Therapeutic Class
- Other Antifungal preparations
Reconstitution
- Shake the bottle well before adding water to loosen the powder
- Specific instructions for adding water and storing reconstituted suspension
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C, protected from light
- Different storage conditions for Voriderm powder for suspension