Rolac NS 15.75 mg/actuation (Nasal Spray)

5 ml nasal spray: ৳ 170.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Renata limited
Also available as
Rolac 10 mg tablet Rolac 10 mg injection Rolac 30 mg injection Rolac 60 mg injection Rolac mdt 10 mg tablet

Indications

  • Management of moderate to severe post-operative pain
  • Relief of pain and inflammation after ocular surgery
  • Reduction of eye inflammation or redness due to allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Highly protein bound
  • Largely metabolized in the liver
  • Excretion of metabolism products and some unchanged drugs in the urine

Pharmacology

  • Potent analgesic NSAID
  • Inhibits cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Recommended tablet dose: 10 mg every 4-6 hours for short-term use
  • Injection may be used for moderately severe, acute pain
  • IM administration should be given slowly and deeply into the muscle
  • Onset of analgesic effect within 30 minutes for IV or IM
  • Duration of analgesic effect usually 4 to 6 hours

Interaction

  • Other NSAIDs or aspirin increase side effects
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blockers reduce anti-hypertensive effect
  • ACE Inhibitors increase risk of renal impairment
  • Methotrexate enhances toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Not for use in children under 16 years
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastrointestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • FDA Pregnancy category: C
  • Avoid use in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use of topical NSAIDs in case of corneal epithelial breakdown
  • Do not administer while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of reach of children

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