Corestin 5 mg (Tablet)

Title

• Corestin 5 mg Tablet

Categories

• Medicine
• Healthcare
• Pharmaceutical

Description

• HMG-CoA Reductase Inhibitor for Lowering Cholesterol

Indications

• Heterozygous Hypercholesterolemia
• Homozygous Hypercholesterolemia
• Mixed Dyslipidemia
• Primary prevention of cardiovascular disease

Pharmacology

• Selective and competitive inhibitor of HMG-CoA reductase
• Increases hepatic LDL receptors
• Inhibits hepatic synthesis of VLDL

Dosage

• Dose range: 5-40 mg once daily
• Starting dose 20 mg/day for HoFH
• Pediatric dose: 5-20 mg/day for specific age groups

Administration

• Can be taken with or without food, at any time of day

Interaction

• Drug interactions with Cyclosporine, Gemfibrosil, Lopinavir/Ritonavir, Atazanavir/ritonavir, Coumarin anticoagulants, Concomitant lipid-lowering therapies

Contraindications

• Known hypersensitivity to product components
• Liver disease
• Pregnant or nursing women

Side Effects

• Headache
• Myalgia
• Constipation
• Asthenia
• Abdominal pain
• Nausea

Pregnancy & Lactation

• Safety not established in pregnant women
• Unknown excretion in human milk

Precautions & Warnings

• Risks increase with 40 mg dose
• Advanced age, hypothyroidism, renal impairment
• Prompt reporting of unexplained muscle pain, tenderness or weakness
• Monitoring of liver enzymes

Use in Special Populations

• Safety and effectiveness not established in pediatric patients

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs
• Statins

Storage Conditions

• Keep below 30°C temperature
• Protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C22H28FN3O6S

Common Questions

• What is Corestin 5 mg Tablet?
• Uses of Corestin 5 mg Tablet
• Side effects of Corestin 5 mg Tablet
• Duration of treatment with Corestin 5 mg Tablet
• Effect of Corestin 5 mg Tablet on weight gain
• Potential tiredness caused by Corestin 5 mg Tablet
• Foods to be avoided when taking Corestin 5 mg Tablet
• Beneficial effects of Corestin 5 mg Tablet
• Potential memory loss caused by Corestin 5 mg Tablet
• Risk of diabetes associated with Corestin 5 mg Tablet
• Alcohol consumption with Corestin 5 mg Tablet
• Muscle problems or injuries associated with Corestin 5 mg Tablet
• Quick Tips

Main Function

• Lowering cholesterol levels
• Reducing triglycerides in the body

Chemical Components

• C22H28FN3O6S

Usability Features

• Safe to take with exercise and low-fat diet
• Should be monitored for liver function
• Not recommended for pregnant or breastfeeding individuals

Special Precautions

• Avoid high dosage in specific populations
• Monitoring for muscle pain and liver enzymes

Excretion in Human Milk

• Unknown

Temperature Storage

• Below 30°C

Light and Moisture Protection

• Protected from light and moisture

Age-specific Dosage

• Different doses for specific age groups

Interaction with Other Drugs

• Interactions with specific drugs mentioned
• Increased exposure for specific combinations

Adverse Events

• Headache
• Abdominal pain
• Myalgia
• Constipation

Liver Health Monitoring

• Monitoring of liver enzymes before and during treatment

Pediatric Safety

• Safety and effectiveness not established in pediatric patients

Chemical Formula

• C22H28FN3O6S

Generic Name

• Rosuvastatin

Dose Range

• 5-40 mg once daily

Starting Dose for HoFH

• 20 mg/day

Pediatric Dose for HeFH

• 5-10 mg/day for 8 to less than 10 years age
• 5-20 mg/day for 10 to 17 years of age

Pediatric Dose for HoFH

• 20 mg/day for 7 to 17 years of age

Liver Enzyme Abnormalities

• Persistent elevations in hepatic transaminases

Liver Function Monitoring

• Before and during treatment

Drug Interactions

• Cyclosporine
• Gemfibrosil
• Lopinavir/Ritonavir
• Atazanavir/Ritonavir
• Coumarin anticoagulants
• Concomitant lipid-lowering therapies

Cholesterol-lowering Effects

• Increases hepatic LDL receptors
• Reduces hepatic synthesis of VLDL

Safety in Pregnancy

• Not established

Alcohol Consumption

• Not recommended during treatment

Muscle Effects

• Risk increases with specific conditions and drug combinations

Blood Sugar Levels

• May cause an increase, especially in those at risk of diabetes

Pediatric Use

• Safety and effectiveness not established

Junk Food Avoidance

• Advised to eat a low-cholesterol diet

Memory Loss Potential

• Very unusual side effect
• Requires immediate medical attention

Memory Loss Risks

• Can occur as a very unusual side effect

Liver Problems Risk

• Increased risk with alcohol consumption

Liver Problem Signs

• Stomach pains
• Dark urine
• Yellowing of skin or eyes

Adverse Muscle Effects

• Muscle pain
• Weakness

Liver Function Checks

• Before starting treatment and regularly thereafter

Liver Disease Risk

• Increased risk with alcohol consumption

Pediatric Effectiveness

• Not established

Pediatric Safety and Effectiveness

• Not established

Pediatric Monitoring

• Monitoring for safety and effectiveness

Pediatric Liver Function

• Monitoring before and during treatment

Generic Equivalent

• Rosuvastatin

HMG-CoA Reductase Inhibitor

• Yes

Uses

• Lowering cholesterol levels
• Reducing triglycerides in the body

Non-Familial Heterozygous Hypercholesterolemia

• Yes

Familial Heterozygous Hypercholesterolemia

• Yes

Homozygous Hypercholesterolemia

• Yes

Fredrickson Type IIA Dyslipidemia

• Yes

Fredrickson Type IIB Dyslipidemia

• Yes

Primary Prevention of Cardiovascular Disease

• Yes

Hypothyroidism Risks

• Increased risk with 40 mg dose

Renal Impairment Risks

• Increased risk with 40 mg dose

Rhabdomyolysis Risk Factors

• Advanced age (>65 years)
• Hypothyroidism
• Renal impairment

Skeletal Muscle Effects Monitoring

• Prompt reporting of muscle symptoms

International Normalized Ratio Monitoring

• Prior to starting treatment
• Frequent monitoring upon initiation or alteration of therapy

Liver Monitoring Requirements

• Before and during treatment

Liver Transaminase Levels

• Persistent elevations can occur

Diabetes Risk Monitoring

• Regular monitoring of blood sugar levels

Carry out INR Monitoring

• Stable INR should be achieved prior to starting treatment

Adult Dosage Range

• 5-40 mg once daily

Pediatric Dosage Range

• 5-20 mg/day for specific age groups

Pediatric HoFH Dosage

• 20 mg/day

Pediatric HeFH Dosage

• 5-10 mg/day for 8 to less than 10 years age
• 5-20 mg/day for 10 to 17 years of age

Alcohol and Triglyceride Levels

• Alcohol can increase triglyceride levels

Alcohol and Liver Health

• Increases the risk of liver problems

Weight Gain Potential

• Very rare side effect
• Not associated with the medicine

Tiredness Potential

• Common side effect

Memory Loss

• Very unusual side effect
• Requires immediate medical attention

Diabetes Risk

• Enhances the risk factor in high-risk individuals

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