Trihexy 5 mg/5 ml (Syrup)
50 ml bottle: ৳ 126.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct treatment for parkinsonism
- Control of extrapyramidal disorders
Description
- Direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located muscarinic receptors
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Optimal daily total of 6 to 10 mg for idiopathic parkinsonism
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or CNS depressants
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Delusions
- Hallucinations
- Paranoia
Pregnancy & Lactation
- Use only when clearly needed and benefit outweighs risk
- Caution in nursing women due to potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Monitoring of intraocular pressures
- Caution in hot weather and with atropine-like drugs
- Possibility of hyperthermia with anhidrosis
- Neuroleptic Malignant Syndrome (NMS) has been reported
Overdose Effects
- Rare cases of death associated with overdose
- Central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, seizures, and coma
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light