Clacef (125 mg+31.25 mg)/5 ml (Powder for Suspension)

70 ml bottle: ৳ 265.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Osl pharma limited
Also available as
Clacef 125 mg tablet Clacef 250 mg tablet Clacef 500 mg tablet

Brand Name

Clacef 125 Syrup

Therapeutic Class

Second generation Cephalosporins

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
  • Lower respiratory tract infections including pneumoniae caused by various bacteria
  • Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
  • Uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae
  • Bone and Joint Infections caused by Staphylococcus aureus
  • Uncomplicated Gonorrhoea caused by Neisseria gonorrhoeae
  • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
  • Septicemia caused by various bacteria
  • Meningitis caused by various bacteria
  • Switch therapy (Injectable to oral)

Pharmacology

Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains.

Mode of Action

Inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.

Dosage & Administration

  • Adolescents and adults (13 years and older):
    • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
    • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
    • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
    • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
    • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
    • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
    • Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose
    • Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
    • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
    • Early Lyme disease: 500 mg b.i.d. for 20 days
  • Paediatric Patients (3 months to 12 years):
    • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
    • Acute otitis media: 30 mg/kg/day b.i.d for 10 days
    • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
    • Impetigo: 30 mg/kg/day b.i.d for 10 days
  • Instructions: Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Contraindications

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Renal dysfunction (rare)
  • Anaphylaxis (rare)
  • Angioedema (rare)
  • Pruritis (rare)
  • Rash (rare)
  • Serum sickness like urticaria (rare)

Pregnancy & Lactation

Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. It is excreted into the breast milk in small quantities.

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Commonly Asked Questions

  • What is Clacef 125 Syrup?: Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Clacef 125 Syrup is indicated for the treatment of infections caused by sensitive bacteria.
  • Clacef 125 Syrup Used For: Treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.
  • How long does it take for Clacef 125 Syrup to take effect?: Starts working within 2-3 hours after taking it.
  • How long do the effects of this medicine last?: Lasts for an average duration of 4-8 hours.
  • Is Clacef 125 Syrup safe to consume alcohol while taking this medicine?: Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is Clacef 125 Syrup a habit forming medicine?: No habit-forming tendencies were reported for Clacef 125 Syrup.
  • Can this medicine be taken during pregnancy?: Safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.
  • Can Clacef 125 Syrup be taken while breast-feeding?: Safe to use during breastfeeding. It enters into breast milk at low levels.
  • Quick Tips:
    • Prescribed to treat bacterial infections
    • Do not skip any doses and finish the full course of treatment
    • Take it with food to avoid an upset stomach
    • Stop taking and inform your doctor immediately if you develop serious symptoms

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