Probal-D 500 mg+200 IU (Tablet)

Indications

• Treatment & prevention of Osteoporosis
• Treatment & prevention of Osteomalacia
• Treatment & prevention of Tetany
• Treatment & prevention of Hypoparathyroidism
• Treatment & prevention of Disorders of osteogenesis
• Supplement in case of inadequate intake of Calcium in childhood diet
• Supplement in case of inadequate intake of Calcium in pregnancy
• Supplement in case of inadequate intake of Calcium in lactation
• Treatment of pancreatitis
• Phosphate binder in chronic renal failure

Composition

• Each tablet contains Calcium Carbonate USP 1250 mg (Coral source)
• Each tablet contains Vitamin D USP 200 IU
• Each DX tablet contains Calcium Carbonate USP 1500 mg (Coral source)
• Each DX tablet contains Vitamin D USP 400 IU
• Each effervescent tablet contains Calcium Carbonate (Coral source) USP 1500 mg
• Each effervescent tablet contains Vitamin D3 400 IU as Cholecalciferol USP

Pharmacology

• Adequate Calcium is vital for bodily functions
• Clinical evidence suggests usefulness for prevention and treatment of Osteoporosis
• Vitamin D aids in Calcium absorption and stimulates bone formation
• Coral Calcium has similar structure to human bone
• Vitamin D3 aids in Calcium absorption from GI tract
• Vitamin D3 helps maintain Calcium balance in the body

Dosage & Administration

• One tablet once or twice daily with plenty of water
• Dissolve 1 effervescent tablet in a glass of water to drink orally

Interaction

• Thiazide diuretics reduce urinary excretion of calcium
• Systemic corticosteroids reduce calcium absorption
• Ion exchange resins may reduce gastrointestinal absorption of vitamin D
• Calcium carbonate may interfere with the absorption of tetracycline preparations
• Hypercalcaemia may increase toxicity of cardiac glycosides
• Bisphosphonate or sodium fluoride intake may reduce calcium tablet absorption

Contraindications

• Hypercalcemia
• Hyperparathyroidism
• Hypercalciuria
• Nephrolithiasis
• Hypersensitivity to the component
• Severe renal insufficiencies
• Concomitant digoxin therapy

Side Effects

• GI irritation
• Constipation
• Hypercalcemia
• Allergic reactions
• Irregular heartbeats
• Nausea
• Vomiting
• Decreased appetite
• Dry mouth
• Drowsiness
• Skin rash (from Vitamin D Supplements)

Pregnancy & Lactation

• Daily intake during pregnancy should not exceed 1500 mg calcium and 600 IU cholecalciferol
• Reproductive toxicity with high dose of vitamin D in animals
• Avoid overdoses as permanent hypercalcaemia may affect the developing fetus

Precautions & Warnings

• Monitor serum calcium levels during long-term treatment
• Monitor renal function through measurement of serum creatinine
• Caution with concomitant treatment with other medications
• Monitor calcium and phosphate levels in patients with impairment of renal function
• Consider risks of soft tissue calcification

Overdose Effects

• Hypervitaminosis D
• Hypercalcaemia
• Symptoms include anorexia, nausea, vomiting, constipation, muscle weakness, fatigue
• Treatment includes discontinuation of treatment and rehydration

Therapeutic Class

• Specific mineral & vitamin combined preparations

Storage Conditions

• Store below 30°C
• Protect from light & moisture
• Keep out of reach of children

Common Questions about Probal-D 500 mg Tablet

• Used to prevent and treat calcium and vitamin D deficiency
• Benefits include prevention of osteoporosis, rickets, osteomalacia
• Shouldn't be taken in specific medical conditions
• Common side effects include constipation, nausea, vomiting, headache, drowsiness

Related Brands

• Reef-D Vita 600 mg+400 IU (Tablet) - healthcare-pharmaceuticals-ltd
• Corcal DX 600 mg+400 IU (Tablet) - osl-pharma-limited
• Lifecal-D 500 mg+200 IU (Tablet) - naafco-pharma-ltd
• Ostocare DX 600 mg+400 IU (Tablet) - concord-pharmaceuticals-ltd
• Ostocare D 500 mg+200 IU (Tablet) - concord-pharmaceuticals-ltd