Ropitor 10 mg (Tablet)

Unit Price: ৳ 23.00 (2 x 14: ৳ 644.00)
Strip Price: ৳ 322.00

Medicine Details

Category Details
Generic Rosuvastatin calcium
Company Opsonin pharma ltd
Also available as
Ropitor 5 mg tablet Ropitor 20 mg tablet

Product Title

  • Ropitor 10 mg Tablet

Categories

  • Medicine
  • Cholesterol-lowering Drug
  • Statins
  • HMG-CoA reductase inhibitor

Description

  • Ropitor is indicated in the treatment of Heterozygous Hypercholesterolemia (Familial and Non familial), Homozygous Hypercholesterolemia (Familial), Mixed Dyslipidemia (Fredrickson Type IIa and IIb), and for the primary prevention of cardiovascular disease. It is a selective and competitive inhibitor of HMG-CoA reductase, with lipid-modifying effects that help in lowering LDL cholesterol and reducing the total number of VLDL and LDL particles.

Dosage Range

  • 5-40 mg once daily

Dose for HoFH

  • Starting dose: 20 mg/day

Dose for Pediatric HeFH

  • 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age

Dose for Pediatric HoFH

  • 20 mg/day for patients 7 to 17 years of age

Administration

  • Can be taken with or without food, at any time of day

Interaction 1

  • Remarkable drug interaction with Cyclosporine: Combination increases Ropitor exposure. Ropitor dose should be limited to 5 mg once daily

Interaction 2

  • Remarkable drug interaction with Gemfibrosil: Combination should be avoided. If used together, Ropitor dose should be limited to 10 mg once daily

Interaction 3

  • Remarkable drug interaction with Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Ropitor exposure. Ropitor dose should be limited to 10 mg once daily

Interaction 4

  • Remarkable drug interaction with Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Ropitor. INR should be monitored frequently until stable upon initiation or alteration of Ropitor therapy

Interaction 5

  • Use with fibrates and niacin products may increase the risk of skeletal muscle effects

Contraindications

  • Known hypersensitivity to product components
  • Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
  • Pregnant women and women who may become pregnant
  • Nursing mothers

Side Effects

  • Headache
  • Myalgia
  • Constipation
  • Asthenia
  • Abdominal pain
  • Nausea

Pregnancy & Lactation

  • The safety in pregnant women has not been established
  • It is not known whether Rosuvastatin is excreted in human milk or not

Precautions & Warnings 1

  • Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Ropitor can be discontinued if signs or symptoms appear

Precautions & Warnings 2

  • Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur. Liver enzymes should be monitored before and during treatment

Use in Special Populations

  • The safety and effectiveness in pediatric patients have not been established

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep below 30C temperature, protected from light & moisture
  • Keep out of the reach of children

Molecular Formula

  • C22H28FN3O6S

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