Evaglip 10 mg+5 mg (Tablet)

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Healthcare pharmaceuticals ltd
Also available as
Evaglip 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improving glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Linagliptin inhibits DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Empagliflozin inhibits SGLT2
  • Reduces renal reabsorption of glucose

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Taken in the morning
  • Can be taken with or without food
  • Increased dose to 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2

Interaction

  • Coadministration with diuretics
  • Coadministration with Insulin or Insulin secretagogues
  • Impact of Rifampin on Linagliptin exposure
  • Positive urine glucose test
  • Interference with 1,5-anhydroglucitol (1,5-AG) assay

Contraindications

  • Severe renal impairment or end-stage renal disease
  • Hypersensitivity to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Insulin
  • Necrotizing Fasciitis
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters
  • Limited available data in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Pancreatitis
  • Hypotension
  • Acute kidney injury
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity
  • Necrotizing Fasciitis
  • Heart Failure

Overdose Effects

  • Contact Poison Control Center
  • Usual supportive measures
  • Hemodialysis for Empagliflozin

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Below 30°C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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