Ardance-L 10 mg+5 mg (Tablet)

Unit Price: ৳ 35.00 (3 x 10: ৳ 1,050.00)
Strip Price: ৳ 350.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Pharmacil limited
Also available as
Ardance l 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases concentrations of active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Regulates glucose homeostasis
  • Inhibits Sodium-glucose co-transporter 2 (SGLT2)

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Increases to 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2

Interaction

  • Coadministration with diuretics increases urine volume
  • Risk for hypoglycemia with insulin or insulin secretagogues
  • Inducers of P-glycoprotein or CYP3A4 enzymes may reduce efficacy
  • Increases urinary glucose excretion
  • Interference with 1,5-anhydroglucitol (1,5-AG) assay

Contraindications

  • Severe renal impairment or end-stage renal disease
  • Hypersensitivity reactions to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Necrotizing Fasciitis of the Perineum
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended in second and third trimesters
  • Limited data available in pregnant women
  • Risks associated with poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Pancreatitis
  • Hypotension
  • Acute kidney injury
  • Impairment in renal function
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity
  • Necrotizing Fasciitis of the Perineum
  • Heart Failure

Overdose Effects

  • Contact Poison Control Center
  • Usual supportive measures
  • Removal of unabsorbed material from the gastrointestinal tract

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30°C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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