Telmivas 80 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Indications

  • Treatment of essential hypertension in adults
  • Reduction of cardiovascular morbidity in individuals with atherothrombotic cardiovascular disease or type 2 diabetes mellitus with documented target organ damage

Pharmacology

  • Non-peptide angiotensin-II receptor antagonist
  • Blocks vasoconstrictor and aldosterone-secreting effects of angiotensin-II
  • Selective blocking of the binding of angiotensin-II to the AT1 receptor
  • Greater affinity for the AT1 receptor than for the AT2 receptor
  • Independence from pathways for angiotensin-II synthesis

Dosage & Administration

  • Usual starting dose of 40 mg once a day
  • Dose-related blood pressure response in the range of 20 to 80 mg
  • Most antihypertensive effect apparent within 2 weeks
  • Maximal reduction generally attained after 4 weeks
  • No initial dosage adjustment necessary for elderly patients or those with renal impairment
  • May be administered with other antihypertensive agents
  • May be administered with or without food
  • Not recommended for patients ≥75 years old or with hepatic impairment
  • Monitoring and slow titration in patients with biliary obstructive disorders or hepatic insufficiency

Interaction

  • Increased risk of renal impairment and loss of antihypertensive effect with NSAIDs
  • Avoid co-administration with aliskiren in patients with diabetes

Contraindications

  • Known hypersensitivity to the product or any of its components

Side Effects

  • Common side effects in hypertensive patients: sinus pain, congestion, back pain, diarrhea
  • Common side effects in patients of cardiovascular risk reduction: intermittent claudication, skin ulcer

Pregnancy & Lactation

  • Pregnancy Category C (first trimester) and D (second and third trimester)
  • Potential for adverse effects on the nursing infant
  • Consideration of discontinuation of nursing or the drug, accounting for the drug's importance to the mother

Precautions & Warnings

  • Avoid fetal or neonatal exposure
  • Hypotension
  • Monitoring in patients with impaired hepatic or renal function
  • Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker

Overdose Effects

  • Hypotension
  • Dizziness
  • Tachycardia
  • Bradycardia
  • Increase in serum creatinine
  • Acute renal failure

Therapeutic Class

  • Angiotensin-II receptor blocker

Storage Conditions

  • Do not store above 30°C
  • Protect from light and high humidity
  • Keep out of the reach of children

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