Telmivas AM 5 mg+80 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Amlodipine besilate telmisartan
Company Popular pharmaceuticals ltd
Also available as
Telmivas am 5 mg tablet

Title

  • Telmisartan & Amiodipine Tablets

Categories

  • Antihypertensive
  • Fixed Dose Combination
  • Hypertension Therapy

Description

  • Combination of Telmisartan and Amiodipine for the treatment of hypertension alone or with other antihypertensive agents.
  • Fixed dose combination with specific pharmacological actions on the renin-angiotensin system and calcium ion influx into vascular and cardiac muscle.
  • Dosage includes initial therapy, add-on therapy, and replacement therapy for blood pressure control.
  • No clinically significant interactions with various medications.
  • Contraindications for known hypersensitivity, pregnancy & lactation, biliary obstructive disorders, severe hepatic impairment, hypotension, and cardiogenic shock.
  • Common side effects include dizziness, peripheral edema, migraine, headache, hypotension, cough, abdominal pain, diarrhea, nausea, fatigue, and more.
  • Pregnancy categories C and D. Precautions for hypotension, hepatic impairment, heart failure, and concomitant use of ACE inhibitor and angiotensin receptor blocker.
  • Not established for pediatric use. Not recommended for initial therapy in patients over 75 years old or with hepatic impairment.

Dimensions

Color Options

Functions

  • Treatment of hypertension
  • Blood pressure control
  • Vasodilation
  • Reduction of peripheral vascular resistance

Materials

Technical Specifications

  • Fixed dose combination of Telmisartan and Amiodipine
  • Telmisartan acts as a non-peptide angiotensin receptor blocker
  • Amiodipine is a dihydropyridine calcium-channel blocker

Design Elements

Usability Features

  • Initial therapy dosage: 40/5 mg once daily
  • Add-on therapy for patients not adequately controlled with individual components
  • Replacement therapy for patients on separate tablet regimens
  • Maximum recommended dosage: 80/10 mg once daily

Indications

  • Treatment of hypertension alone or with other antihypertensive agents

Pharmacology

  • Telmisartan acts on the AT1 subtype of angiotensin II receptor
  • Telmisartan dilates blood vessels and reduces blood pressure without affecting pulse rate
  • Amiodipine inhibits the transmembrane influx of calcium ion into vascular smooth muscle and cardiac muscle
  • Amiodipine causes a reduction in peripheral vascular resistance and blood pressure

Dosage & Administration

  • Usual starting dose: 40/5 mg once daily
  • Initial therapy not recommended in patients over 75 years old or with hepatic impairment
  • Individualized dosage and potential increase after 2 weeks
  • Maximum recommended dose: 80/10 mg once daily

Interaction

  • No clinically significant interactions with acetaminophen, glyburide, simvastatin, hydrochlorothiazide, warfarin, ibuprofen, thiazide diuretics, beta-blockers, etc.
  • Possible inhibition of CYP2C19 metabolism by telmisartan

Contraindications

  • Known hypersensitivity to the product or its components
  • Pregnancy & lactation
  • Biliary obstructive disorders
  • Severe hepatic impairment
  • Hypotension
  • Cardiogenic shock
  • Left ventricle outflow tract obstruction

Side Effects

  • Dizziness
  • Peripheral edema
  • Migraine
  • Headache
  • Hypotension
  • Cough
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Fatigue

Pregnancy & Lactation

  • Pregnancy Categories C and D
  • Potential adverse effects on the nursing infant
  • Discontinuation of nursing or drug intake after considering the importance of the drug to the mother

Precautions & Warnings

  • Avoid fetal or neonatal exposure
  • Correction of volume or salt depletion before initiating therapy
  • Slow titration in patients with hepatic or severe renal impairment
  • Monitoring for worsening heart failure
  • Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker
  • Possible myocardial infarction in patients with severe obstructive coronary artery disease

Use in Special Populations

  • Not established for pediatric use
  • Not recommended for initial therapy in patients over 75 years old or with hepatic impairment

Overdose Effects

  • Telmisartan overdose: hypotension, dizziness, tachycardia
  • Supportive treatment for symptomatic hypotension
  • Amiodipine overdose: excessive peripheral vasodilation, hypotension, reflex tachycardia
  • Cardiac and respiratory monitoring for massive overdose

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Protect from light and high humidity
  • Keep out of the reach of children

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