Ursotab 150 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Ursodeoxycholic acid
Company Beacon pharmaceuticals plc
Also available as
Ursotab 300 mg tablet

Indication

  • Cholestasis (Jaundice)
  • Viral Hepatitis
  • Alcoholic Fatty Liver
  • Primary Billiary Cirrhosis (PBC)
  • Primary Sclerosing Cholangitis (PSC)
  • Dissolution of Gallstones
  • Non-Alcoholic Steato Hepatitis (NASH)

Description

Reduction of cholesterol saturation of bile, promotion of dissolution of gallstones, reduction of cholesterol secretion into bile, and increased bile acid secretion rate during treatment without a reduction in phospholipids.

Pharmacology

  • Main function: Decrease in secretion of cholesterol in bile
  • Mechanisms:
    • Reduces cholesterol absorption
    • Suppresses liver cholesterol synthesis
    • Does not inhibit bile acid synthesis
  • Other functions:
    • Protects cholangiocytes against cytotoxicity of hydrophobic bile acids
    • Stimulates hepatobilliary secretion
    • Protects hepatocytes against bile acid-induced apoptosis
  • Absorption:
    • Absorption rate: 60-80%
    • Maximum serum concentration time: 30-150 minutes
    • Absorption location: Upper intestine
    • Excretion:
      • Route: Urinary
      • Biologic half life: 3.5-5.8 days

Dosage and administration

  • Dissolution gallstones: 8-12 mg/kg/day as single night time dose or in divided doses
  • Primary billiary cirrhosis: 10-15 mg/kg/day in 2-4 divided doses
  • Acute viral hepatitis: 600 mg/day
  • Alcoholic fatty liver: 300 mg/day
  • Primary sclerosing cholangitis: 25-30 mg/kg/day
  • Dissolution gallstones nash: 13-15 mg/kg/day

Interaction

Should not be used with drugs that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal, and cholestyramine should be avoided, as this may reduce the effectiveness of therapy.

Contraindications

  • Non-functioning gall-bladder
  • Calcified and pigmented gallstones
  • Inflammatory bowel disease

Side effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Gallstone opacilication
  • Pruritus

Pregnancy and lactation

  • Pregnancy category: Category B
  • Effects in pregnancy: No evidence of harm reported
  • Effects in breast feeding: No documented problems

Precautions and warnings

Cautious use in those with liver disease

Therapeutic class

Anti-gallstones drugs: Bile Acids

Storage conditions

Store below 25°C, protected from light and moisture, keep out of reach of children

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