Rostatin 20 mg (Tablet)

Unit Price: ৳ 14.00 (1 x 14: ৳ 196.00)
Strip Price: ৳ 196.00

Medicine Details

Category Details
Generic Rosuvastatin calcium
Company Drug international ltd
Also available as
Rostatin 5 mg tablet Rostatin 10 mg tablet

Indications

  • Heterozygous Hypercholesterolemia (Familial and Non familial)
  • Homozygous Hypercholesterolemia (Familial)
  • Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
  • Primary prevention of cardiovascular disease

Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol.

Dosage

  • 5-40 mg once daily
  • HoFH: Starting dose 20 mg/day
  • Pediatric patients with HeFH: 5-10 mg/day (8 to less than 10 years age) and 5-20 mg/day (10 to 17 years of age)
  • Pediatric patients with HoFH: 20 mg/day (7 to 17 years of age)

Administration

Rosuvastatin can be taken with or without food, at any time of day.

Interaction

  • Cyclosporine: Combination increases Rostatin exposure. Rostatin dose should be limited to 5 mg once daily.
  • Gemfibrosil: Combination should be avoided. If used together, Rostatin dose should be limited to 10 mg once daily.
  • Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rostatin exposure. Rostatin dose should be to 10 mg once daily.
  • Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved prior to starting Rostatin. INR should be monitored frequently until stable upon initiation or alteration of Rostatin therapy.
  • Concomitant lipid-lowering therapies: Use with fibrates and niacin products may increase the risk of skeletal muscle effects.

Contraindications

  • Known hypersensitivity to product components
  • Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
  • Pregnant women and women who may become pregnant
  • Nursing mothers

Side Effects

Frequent adverse events thought to be related to Rostatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.

Precautions & Warnings

  • Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with certain other lipid-lowering drugs.
  • Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur. Liver enzymes should be monitored before and during treatment.

Use in Special Populations

The safety and effectiveness in pediatric patients have not been established.

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C22H28FN3O6S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-970-rosuvastatin-calcium-chemical-structure-UjXgzBvpDHiLnIP3gZua.svg

Common Questions

  • What is Rostatin 20 mg Tablet?: Rostatin 20 mg Tablet is a HMG-CoA reductase inhibitor drug which is helpful in lowering the cholesterol level and triglycerides in the body.
  • What are the uses of Rostatin 20 mg Tablet?: Rostatin 20 mg Tablet is useful against the conditions like Hyperlipidemia, Hypertriglyceridemia, Type 3 Hyperlipoproteinemia and Stroke.
  • What are the side effects of Rostatin 20 mg Tablet?: Side effects of Rostatin 20 mg Tablet include Muscle pain, Weakness, Headache and Abdominal pain.
  • For how long should I take Rostatin 20 mg Tablet?: Rostatin 20 mg Tablet should be taken till you see improvement in your medical condition. Follow your doctor’s instructions to know the duration for Rostatin 20 mg Tablet.
  • Does Rostatin 20 mg Tablet cause weight gain?: Weight gain is a very rare side effect of Rostatin 20 mg Tablet. This medication does not lead to weight gain and in case you are observing this symptom, please consult a doctor for diagnosis.
  • Does Rostatin 20 mg Tablet make you tired?: Tiredness and fatigue is a common side effect of Rostatin 20 mg Tablet however, the exact reason behind it is still not known. Consult a doctor if it persists for a longer duration of time.
  • Should Rostatin 20 mg Tablet be taken at night?: Rostatin 20 mg Tablet is not mandatory to take Rostatin 20 mg Tablet at night. You can take it in the morning too, however, it should be consumed once a day only. Ideally, you must follow your doctor’s instructions regarding the dosage.
  • What foods should be avoided when taking Rostatin 20 mg Tablet?: Avoid eating junk food and foods that are high in calories as they can increase the cholesterol levels. You must eat only a low-cholesterol diet during the course of Rostatin 20 mg Tablet treatment.
  • How do I know whether Rostatin 20 mg Tablet is beneficial for me or not?: If you start noticing improvement in your condition, then Rostatin 20 mg Tablet is beneficial for you. In case, you do not see any positive effects of Rostatin 20 mg Tablet or experience adverse side effects after consuming this medicine, then consult a doctor to know a safer substitute of Rostatin 20 mg Tablet.
  • Can Rostatin 20 mg Tablet cause memory loss?: Memory loss is a very unusual side effect that can occur. If this symptom occurs, stop taking this medicine and consult a doctor immediately.
  • Is it true that Rostatin 20 mg Tablet can cause diabetes?: This medicine does not cause diabetes, however, if you already are at higher risk of having this disorder, then this medicine can enhance the risk factor by increasing the blood sugar levels. In such a case, regular monitoring of blood sugar level is mandatory.
  • Can I take alcohol with Rostatin 20 mg Tablet?: Do not take alcohol during the course of treatment with this medicine as it can increase the risk of having liver problems. Also, alcohol can increase the levels of triglyceride levels in the body.
  • Can Rostatin 20 mg Tablet cause muscle problems or muscle injury?: Muscle pain or any other problem associated with muscles is the most common side effect of this medicine. Consult your doctor if this side effect is causing discomfort in doing day to day activities.
  • Quick Tips:
    • Rostatin 20 mg Tablet treats high cholesterol by lowering 'bad' cholesterol (LDL) and triglycerides (fats). It should be taken in addition to regular exercise and low-fat diet.
    • In general, Rostatin 20 mg Tablet is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.
    • Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
    • Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
    • Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Rostatin 20 mg Tablet may cause an increase in your blood sugar level.
    • Do not take Rostatin 20 mg Tablet if you are pregnant, planning a pregnancy or breastfeeding.

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