Fulvestrant 250 mg/5 ml (IM Injection)
5 ml pre-filled syringe: ৳ 25,000.00 (2's pack: ৳ 50,000.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fulvestrant |
| Company | Ever pharma jena gmbh germany |
Title
- Fulvestrant
Categories
- Medicine
- Treatment
Description
- Estrogen receptor antagonist
- Indicated for HR-positive, HER2-negative advanced breast cancer
- Treatment for postmenopausal women
- Blocks the uterotrophic action of estradiol
- Available as 500mg and 250mg doses
Dimensions
- 5 mL injection
- Intramuscular administration into the buttocks
Color Options
- NA
Functions
- Competitive binding to estrogen receptor
- Downregulates ER protein in breast cancer cells
- Inhibits growth of tamoxifen-resistant and estrogen-sensitive breast cancer cell lines
Materials
- NA
Technical Specifications
- Metabolized by CYP 3A4
- Reversible inhibitor of tumor growth in xenografts
- Delayed establishment of tumors in animal studies
Design Elements
- NA
Usability Features
- Monthly administration after initial doses
- Slow intramuscular injection over 1-2 minutes per injection
- No known drug-drug interactions
Indications
- HR-positive, HER2-negative advanced breast cancer treatment
- First-line and subsequent endocrine therapy
Pharmacology
- Estrogen receptor antagonist
- Binds competitively to estrogen receptor
- Downregulates ER protein in human breast cancer cells
Dosage & Administration
- 500mg intramuscular injection into buttocks on Days 1, 15, 29, and monthly thereafter
- 250mg dose recommended for moderate hepatic impairment
Interactions
- No known drug interactions
- Metabolized by CYP 3A4
Side Effects
- Common adverse reactions: injection site pain, nausea, bone pain, arthralgia
- Increased hepatic enzymes in >15% of patients
Pregnancy & Lactation
- No data available for pregnant women
- No information on presence in human milk or effects on breastfed infants
Precautions & Warnings
- Use with caution in patients with bleeding diatheses or thrombocytopenia
- Detailed caution while administering at the dorsogluteal injection site
- Potential risk of embryo-fetal toxicity
Overdose Effects
- Limited human experience with overdose
- No specific treatment established
- Follow general supportive measures
Storage Conditions
- Refrigerate at 2°-8°C
- Store in the original carton to protect from light