Ariplat 1 mg/ml (IV Infusion)
10 mg vial: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Aristopharma ltd |
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum compound
- DNA structure modification
- DNA synthesis inhibition
- Protein and RNA synthesis inhibition
- Non-phase-specific in cell cycle
Dosage & Administration
- Intravenous infusion administration
- Slow intravenous infusion
- No rapid intravenous injection
- Aluminum-free needles and sets
- Dosing based on cancer type
Interaction
- Additive toxicity with similar antineoplastic drugs
- Nephrotoxic drug interactions
- Ototoxic drug interactions
- Renally excreted drug interactions
- Anticonvulsant drug interactions
- Antigout drug interactions
Contraindications
- Pre-existing renal impairment
- History of hypersensitivity to Cisplatin or Platinum compounds
- Myelosuppressed patients
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Renal tubular dysfunction
- Hypomagnesemia
- Hypocalcemia
- Hypokalemia
Pregnancy & Lactation
- Pregnancy Category D
- No well-controlled studies in pregnant women
- Presence in human milk
Precautions & Warnings
- Renal function evaluation
- Serum electrolyte evaluation
- Intravenous infusion over 6 to 8 hours
- Per-treatment hydration
- Bone marrow function monitoring
- Hearing function monitoring
- CNS function monitoring
- Nausea and vomiting management
- Carcinogenicity risk
- Dental care
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Myelosuppression
- Intractable nausea and vomiting
- Neuritis
- Death
- Hemodialysis inefficacy for platinum removal
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in original carton at 25°C
- No refrigeration
- Protection from light
- Keep out of the reach of children