Cistor 1 mg/ml (IV Infusion)
10 mg vial: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cisplatin |
| Company | Eskayef pharmaceuticals ltd |
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Small Cell Lung Carcinoma
Pharmacology
- Platinum compound
- Intra-and interstrand cross links
- DNA structure modification
- Inhibition of DNA, protein, and RNA synthesis
Dosage & Administration
- Administered by slow intravenous infusion
- Not given by rapid intravenous injection
- Avoid needles or intravenous sets containing aluminum parts
Interaction
- Combination with antineoplastic drugs
- Additive toxicity with similar cytotoxic drugs
- Nephrotoxic drugs interaction
- Ototoxic drugs interaction
- Renally excreted drugs interaction
Contraindications
- Pre-existing renal impairment
- History of hypersensitivity to Cisplatin
- Patients with myelosuppression
- Patients with hearing impairment
Side Effects
- Severe nausea and vomiting
- Electrolyte disturbances
- Hypomagnesemia, hypocalcemia, hypokalemia
- Renal tubular dysfunction
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well controlled studies in pregnant women
- Presence in human milk
Precautions & Warnings
- Cumulative nephrotoxicity
- Monitoring of renal function and serum electrolytes
- Peripheral blood counts monitoring
- Audiometry for hearing function
- Neurological examination for neurotoxicity
- Monitoring for anaphylactoid reactions
- Nausea and vomiting management
- Carcinogenicity risk
- Dental precautions
Overdose Effects
- Kidney failure
- Liver failure
- Deafness
- Ocular toxicity
- Significant myelosuppression
- Intractable nausea and vomiting
- Neuritis
- Potential death
- No proven antidotes
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store at 25°C
- Protect from light
- Keep out of the reach of children