Nexe MUPS 20 mg (MUPS Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Apex pharmaceuticals ltd |
Title
- Nexe MUPS 20 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
- Proton pump inhibitor for treating GERD, ulcers, and excessive stomach acid production
- Multiple-Unit Pellet System (MUPS) technology for enhanced drug delivery
- Ensures greater bioavailability and uniform drug absorption
- Combination of fast-acting and sustained action for consistent effect
- Once daily dosing for convenience and adherence
- Esomeprazole inhibits gastric acid production by blocking proton pump
- Clinically proven for short-term treatment of gastric and duodenal ulcers
- Effective in H. pylori eradication with triple therapy regimen
- Available in 20 mg and 40 mg strengths for different treatment needs
- Reduces the risk of NSAID-associated gastric ulcers
Dosage
- 40 mg once daily for 4 weeks for erosive esophagitis in adults
- 20 mg once daily for maintenance of healing in adults and children
- 20 mg twice daily for 7 days for H. pylori eradication in adults and children
- 40-80 mg twice daily for Zollinger-Ellison syndrome in adults
- Specific dosages for children based on weight and age
- Not approved for use in children under 1 year
Composition
- 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP) in each tablet
- 133.333 mg (15%w/w) of Esomeprazole in 20 mg MUPS tablet
- 266.67 mg (15% w/w) of Esomeprazole in 40 mg MUPS tablet
Indications
- Treatment of Gastro-esophageal Reflux Disease (GERD)
- Reduction of risk in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Management of Zollinger-Ellison syndrome and idiopathic hypersecretion
Mode of Action
- Inhibits gastric acid by blocking the proton pump enzyme system
Interaction
- Metabolized by CYP2C19 and CYP3A4 enzymes in the liver
- No clinically significant interactions with many CYP enzymes
- Potential interactions with diazepam, ketoconazole, and iron salts
- Dose reduction may be needed with certain co-administered drugs
Administration
- Tablets should be swallowed whole with liquid
- Can be dispersed in half a glass of water if needed
- Do not chew or crush the tablets
- Ensure tablets disintegrate completely before consumption
Contraindications
- Known hypersensitivity to any components of the formulation
Side Effects
- Common adverse events include headache, diarrhea, nausea, and abdominal pain
- No significant difference in side effects between short and long-term use
Pregnancy & Lactation
- Caution advised during pregnancy and lactation
- Unknown if Esomeprazole or its metabolites pass into breast milk
Precautions & Warnings
- Use with caution in severe liver dysfunction and renal impairment
- Prolonged use may slightly increase the risk of bone fractures
Storage Conditions
- Store below 25°C in a cool, dry place away from light
Chemical Structure
- Molecular Formula: C17H19N3O3S