Nexe MUPS 20 mg (MUPS Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Apex pharmaceuticals ltd

Title

  • Nexe MUPS 20 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Proton pump inhibitor for treating GERD, ulcers, and excessive stomach acid production
  • Multiple-Unit Pellet System (MUPS) technology for enhanced drug delivery
  • Ensures greater bioavailability and uniform drug absorption
  • Combination of fast-acting and sustained action for consistent effect
  • Once daily dosing for convenience and adherence
  • Esomeprazole inhibits gastric acid production by blocking proton pump
  • Clinically proven for short-term treatment of gastric and duodenal ulcers
  • Effective in H. pylori eradication with triple therapy regimen
  • Available in 20 mg and 40 mg strengths for different treatment needs
  • Reduces the risk of NSAID-associated gastric ulcers

Dosage

  • 40 mg once daily for 4 weeks for erosive esophagitis in adults
  • 20 mg once daily for maintenance of healing in adults and children
  • 20 mg twice daily for 7 days for H. pylori eradication in adults and children
  • 40-80 mg twice daily for Zollinger-Ellison syndrome in adults
  • Specific dosages for children based on weight and age
  • Not approved for use in children under 1 year

Composition

  • 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP) in each tablet
  • 133.333 mg (15%w/w) of Esomeprazole in 20 mg MUPS tablet
  • 266.67 mg (15% w/w) of Esomeprazole in 40 mg MUPS tablet

Indications

  • Treatment of Gastro-esophageal Reflux Disease (GERD)
  • Reduction of risk in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Management of Zollinger-Ellison syndrome and idiopathic hypersecretion

Mode of Action

  • Inhibits gastric acid by blocking the proton pump enzyme system

Interaction

  • Metabolized by CYP2C19 and CYP3A4 enzymes in the liver
  • No clinically significant interactions with many CYP enzymes
  • Potential interactions with diazepam, ketoconazole, and iron salts
  • Dose reduction may be needed with certain co-administered drugs

Administration

  • Tablets should be swallowed whole with liquid
  • Can be dispersed in half a glass of water if needed
  • Do not chew or crush the tablets
  • Ensure tablets disintegrate completely before consumption

Contraindications

  • Known hypersensitivity to any components of the formulation

Side Effects

  • Common adverse events include headache, diarrhea, nausea, and abdominal pain
  • No significant difference in side effects between short and long-term use

Pregnancy & Lactation

  • Caution advised during pregnancy and lactation
  • Unknown if Esomeprazole or its metabolites pass into breast milk

Precautions & Warnings

  • Use with caution in severe liver dysfunction and renal impairment
  • Prolonged use may slightly increase the risk of bone fractures

Storage Conditions

  • Store below 25°C in a cool, dry place away from light

Chemical Structure

  • Molecular Formula: C17H19N3O3S

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