Venopex 100 mg/5 ml (IV Injection or Infusion)

5 ml ampoule: ৳ 325.00

Medicine Details

Category Details
Generic Iron sucrose
Company Apex pharmaceuticals ltd

Indications

  • Treatment of Venopex deficiency in various conditions
  • Rapid Venopex supply when clinically needed
  • Patients intolerant to oral Venopex therapy
  • Patients with active inflammatory bowel disease
  • Non-dialysis dependent-chronic kidney disease patients receiving erythropoietin
  • Non-dialysis dependent-chronic kidney disease patients not receiving erythropoietin
  • Hemodialysis dependent-chronic kidney disease patients receiving erythropoietin
  • Peritoneal dialysis dependent-chronic kidney disease patients receiving erythropoietin
  • Treatment of Venopex deficiency anaemia in surgical patients
  • Treatment of Venopex deficiency anaemia in postpartum patients

Pharmacology

  • Therapeutic class: Haematinic
  • Iron Sucrose Injection USP is a brown, sterile, aqueous complex of Polynuclear Iron (III) Hydroxide in Sucrose for Intravenous use
  • Contains approximately 30% Sucrose w/v and has a pH of 10.5-11.1
  • Dissociates into Iron and Sucrose after intravenous administration
  • Iron transfers from blood to liver and bone marrow
  • Ferritin binds and sequesters Iron in a nontoxic form
  • Iron binds to plasma transferrin for distribution to tissues
  • Intracellular Iron becomes haemoglobin in red blood cells

Dosage

  • Adult dosage: 5-10 ml Iron Sucrose Injection (100-200 mg Iron) once to three times a week
  • Limited data for children under study conditions
  • Children dosage: Not to exceed 0.15 ml Iron Sucrose Injection (3 mg Iron) per kg body weight once to three times per week

Administration

  • Intravenous injection at recommended rate
  • Maximum 10 ml Iron Sucrose Injection (200 mg Iron) per injection
  • Test dose before therapeutic dose in new patients
  • Preferably administered by drip infusion in a dilution of 1 ml Iron Sucrose Injection (20 mg Iron) in max. 20 ml 0.9% w/v Sodium Chloride
  • Dilution to take place immediately prior to infusion
  • Infusion time varies with Iron dosage
  • Test dose before therapeutic dose for new patients

Interaction

  • No studied drug-drug interactions with Venopex
  • Do not administer concomitantly with oral iron preparations
  • Oral Venopex therapy should not be given until 5 days after last injection

Contraindications

  • Contraindicated in patients with evidence of Iron overload
  • Known hypersensitivity to Iron Sucrose or any of its inactive components
  • Anaemia not caused by Iron deficiency
  • History of allergic disorders, liver disease, and infections

Side effects

  • Adverse reactions include hypotension, cramps, nausea, headache, vomiting, diarrhea
  • Body as a whole: fever, pain, asthenia, malaise, accidental injury
  • Cardiovascular disorders: chest pain, hypertension, hypervolemia
  • Gastrointestinal disorders: abdominal pain, elevated liver enzymes
  • Central and peripheral nervous system: dizziness
  • Musculoskeletal system: musculoskeletal pain
  • Respiratory system: dyspnea, pneumonia, cough
  • Skin and appendages: pruritus, application site reaction
  • Hypersensitivity reactions: wheezing, dyspnea, anaphylactoid reactions, test dose recommended

Pregnancy and lactation

  • Pregnancy Category-B
  • Use during pregnancy only if clearly needed
  • Not known if excreted in human milk
  • Caution in administering to nursing women

Precautions and warnings

  • Periodic monitoring of hematologic and haematinic parameters required
  • Caution in the presence of evidence of tissue Venopex overload
  • Serious hypersensitivity reactions reported
  • Frequent hypotension in hemodialysis patients receiving intravenous Venopex
  • Adherence to recommended guidelines for administration

Special populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety observed between elderly and younger subjects

Overdose effects

  • Excess dosage may lead to accumulation in storage sites
  • Periodic monitoring of Venopex parameters may assist in recognizing accumulation
  • Caution in avoiding Venopex overload
  • Symptoms associated with overdosage or rapid infusion include hypotension, headache, vomiting, nausea, dizziness, joint aches, paresthesia, and cardiovascular collapse
  • Successful treatment with IV fluids, hydrocortisone, and antihistamines reported

Therapeutic class

  • Parenteral Iron Preparations

Storage conditions

  • Store in a cool (15°C-30°C) and dry place, protected from light
  • Keep out of the reach of children
  • Do not freeze

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