Rosuva 5 mg (Tablet)
Unit Price: ৳ 10.03 (5 x 10: ৳ 501.50)
Strip Price: ৳ 100.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Rosuvastatin calcium |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Rosuva 5 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
- Rosuvastatin is indicated in Heterozygous Hypercholesterolemia, Homozygous Hypercholesterolemia, Mixed Dyslipidemia, and Primary prevention of cardiovascular disease. It is a selective and competitive inhibitor of HMG-CoA reductase, producing lipid-modifying effects by increasing the number of hepatic LDL receptors and inhibiting hepatic synthesis of VLDL and LDL. The dose range is 5-40 mg once daily. It can be taken with or without food at any time of day. Rosuvastatin has remarkable drug interactions with Cyclosporine, Gemfibrosil, Lopinavir/Ritonavir or atazanavir/ritonavir, Coumarin anticoagulants, and concomitant lipid-lowering therapies. It is contraindicated in case of known hypersensitivity, liver disease, pregnancy, and lactation. The most frequent adverse events are headache, myalgia, constipation, asthenia, abdominal pain, and nausea. It is not established for use in children. The therapeutic class includes Other Anti-anginal & Anti-ischaemic drugs and Statins. Rosuvastatin should be stored below 30°C temperature, protected from light & moisture, and out of the reach of children.
Dosage Range
5-40 mg once daily
Recommended Dose for HoFH
- 20 mg/day
Recommended Dose for Pediatric patients with HeFH
- 5-10 mg/day (8 to less than 10 years age)
- 5-20 mg/day (10 to 17 years of age)
Recommended Dose for Pediatric patients with HoFH
- 20 mg/day (7 to 17 years of age)
Administration
Can be taken with or without food, at any time of day
Pharmacology
Selective and competitive inhibitor of HMG-CoA reductase, enhancing uptake and catabolism of LDL and inhibiting hepatic synthesis of VLDL
Interaction
- Cyclosporine increases Rosuva exposure
- Gemfibrosil combination should be avoided
- Lopinavir/Ritonavir or atazanavir/ritonavir combination increases Rosuva exposure
- Coumarin anticoagulants combination prolongs INR
- Concomitant lipid-lowering therapies use may increase the risk of skeletal muscle effects
Contraindications
- Known hypersensitivity to product components
- Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels
- Pregnant women and women who may become pregnant
- Nursing mothers
Side Effects
- Headache
- Myalgia
- Constipation
- Asthenia
- Abdominal pain
- Nausea
Pregnancy & Lactation Safety
Safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not
Precautions & Warnings
- Risks increase with use of 40 mg dose, advanced age (>65 years), hypothyroidism, and renal impairment
- Promptly report unexplained muscle pain, tenderness or weakness
- Liver enzymes should be monitored before and during treatment
- Not established for use in children
Special Populations
- Use in children not established
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children
Chemical Structure
- Molecular Formula: C22H28FN3O6S