Lemodip 5 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Incepta pharmaceuticals ltd |
| Also available as | Lemodip 125 mg tabletLemodip 25 mg tablet |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reducing the risk of cardiovascular events
- Strokes prevention
- Myocardial infarctions prevention
Pharmacology
- Dihydropyridine calcium antagonist
- Inhibition of transmembrane influx of calcium ions
- Selective effect on vascular smooth muscle cells
- Volume of distribution similar to amlodipine
- Metabolized to inactive metabolites
- 90% metabolism by CYP3A4
- 60% elimination in urine
- Tmax of 6-12 hours
- Bioavailability of 64-90%
Dosage & Administration
- Oral route of administration
- Usual initial antihypertensive oral dose of 2.5 mg once daily
- Maximum dose of 5 mg once daily
- Dose adjustment for elderly and hepatic insufficiency patients
- Titration for blood pressure goals
Interaction
- Impact of CYP3A Inhibitors on amlodipine
- Impact of CYP3A Inducers on amlodipine
- Co-administration of simvastatin with amlodipine
- Impact on immunosuppressants
- Can be taken with or without food
- Avoid grapefruit products & natural licorice
Contraindications
- Known sensitivity to amlodipine
Side Effects
- Difficulty in breathing
- Dizziness
- Reflex Tachycardia
- Hypotension
- Abdominal Pain
- Edema
- Diarrhea
- Back pain
- Headache
- Fatigue
- Nausea
Pregnancy & Lactation
- Limited available data on pregnant women
- No adverse effects on the breastfed infant
Precautions & Warnings
- Symptomatic hypotension possible
- Worsening angina
- Acute myocardial infarction potential
- Titration in patients with hepatic impairment
Overdose Effects
- Excessive peripheral vasodilation
- Marked hypotension
- Reflex tachycardia possibility
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Cool & dry place
- Protection from light & moisture
- Keep out of reach of children