Foly 5 mg (Tablet)

Unit Price: ৳ 9.00 (2 x 14: ৳ 252.00)

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Medicine Details

Category	Details
Generic	Folinic acid
Company	Drug international ltd
Also available as	Foly 15 mg tablet Foly 10 mg injection

Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate
The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome

Calcium Folinate Hydrate is a calcium salt of folinic acid, a metabolite and active form of folic acid
Involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidine nucleic acids
Postulated to enter and 'rescue' normal cells from the toxic effects of folic acid antagonists in preference to tumour cells
Potent antidote for hematopoietic and reticuloendothelial toxic effects of folic acid antagonists

Calcium folinate rescue treatment should commence approximately 24 hours after the beginning of methotrexate infusion
Dosage regimens vary depending upon the dose of methotrexate administered
Folinic Acid should be administered at a dose of 15 mg every 6 hours for 10 doses in general
Approximately 5 mg to 15 mg of Folinic Acid per day for counteracting hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase

Folinates in large amounts may counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone
Concurrent administration of calcium folinate with fluoropyrimidine has been associated with seizures and syncope

Known hypersensitivity to calcium folinate or any other components of the product
Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Rare hereditary problems of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption

Caution should be exercised when calcium folinate is administered to a nursing mother due to potential excretion in human milk

Should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
Inadvertent overdosage treatment with folinate should be administered as soon as possible

Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
No specific antidote to calcium folinate overdose
Patients should be given appropriate supportive care in cases of overdosage