Meroject 250 mg/vial (IV Injection or Infusion)

250 mg vial: ৳ 450.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Eskayef pharmaceuticals ltd
Also available as
Meroject 500 mg injection Meroject 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis and shows potent bactericidal activity against a broad spectrum of bacteria.

Dosage

  • Adults:
    • Recommended daily dosage: 500 mg to 1 gm by intravenous administration every 8 hours
    • Dosage variations for different infections
  • Children:
    • Dosage based on type, severity of infection, susceptibility of the pathogens, and the condition of the patient
    • Special dosage considerations for children over 50 kg weight

Administration

Meropenem should be administered by intravenous infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

  • Probenecid: Competes with Meroject for active tubular secretion and thus inhibits the renal excretion

Contraindications

Contraindicated in patients with demonstrated hypersensitivity to this product

Side Effects

  • Inflammation at injection site
  • Thrombophlebitis
  • Skin reactions like rash, pruritus, urticaria
  • Gastrointestinal effects like abdominal pain, nausea, vomiting, diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

  • Allergic Reaction: If an allergic reaction occurs, the drug should be discontinued and appropriate measures taken
  • Hepatic Disease: Use in patients with hepatic disease should be made with careful monitoring of transaminase and bilirubin levels

Use in Special Populations

  • Renal Impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
  • Hepatic Impairment: No dosage adjustments necessary with impairment of liver function

Overdose Effects

Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment of overdose should be symptomatic.

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Instructions for preparation and reconstitution of solution for intravenous bolus and infusion administration, compatibility with various infusion fluids, and recommended use of freshly reconstituted solution

Storage Conditions

Vials should be stored in a cool, dry place (below 30°C), away from light and moisture, and out of the reach of children

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