Cardinor Plus 5 mg+6.25 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Bisoprolol fumarate hydrochlorothiazide
Company Labaid pharma ltd
Also available as
Cardinor plus 25 mg tablet

Title

Cardinor Plus

Categories

  • Medicine
  • Pharmaceutical

Description

Bisoprolol plus Hydrochlorothiazide is indicated in the treatment of Hypertension. Bisoprolol Fumarate and Hydrochlorothiazide have been used individually and in combination for the treatment of hypertension. The antihypertensive effects of these agents are additive; Hydrochlorothiazide 6.25 mg significantly increases the antihypertensive effect of Bisoprolol Fumarate. Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. Generally well tolerated. Most side effects have been mild and transient. Side effects which may occur: fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis etc. Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Bisoprolol Fumarate and Hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus. Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Attributes

  • Treatment Indication: Treatment of hypertension
  • Pharmacological Action: Additive antihypertensive effects
  • Dosage Range: Bisoprolol: 2.5 to 40 mg once daily, Hydrochlorothiazide: 12.5 to 50 mg once daily
  • Initial Therapy Dose: One 2.5/6.25 mg tablet once daily
  • Maximum Recommended Dose: 20/12.5 mg once daily
  • Contraindications:
    • Cardiogenic shock
    • Overt cardiac failure
    • Second or third degree AV block
    • Marked sinus bradycardia
    • Anuria
    • Hypersensitivity to either component or other sulfonamide-derived drugs
  • Common Side Effects:
    • Fatigue
    • Dizziness
    • Headache
    • Bradycardia
    • Arrhythmia
    • Peripheral ischemia
    • Chest pain
    • Palpitations
    • Cold extremities
    • Claudication
    • Orthostatic hypotension
    • Diarrhea
    • Constipation
    • Nausea
    • Dyspepsia
    • Rhinitis
    • Pharyngitis
  • Pregnancy Category: Category C
  • Storage Conditions: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
  • Pharmaceutical Class: Combined antihypertensive preparations
  • Mode of Action: Bisoprolol Fumarate is a β1-selective (cardioselective) adrenoceptor blocking agent without significant membrane stabilizing or intrinsic sympathomimetic activities. Hydrochlorothiazide is a benzothiadiazine diuretic affecting renal tubular mechanisms of electrolyte reabsorption.
  • Interaction Warnings: Potentiation with other antihypertensive agents. Avoid combining with other beta-blocking agents. Monitor closely when used with catecholamine-depleting drugs, clonidine, myocardial depressants, AV conduction inhibitors, digitalis glycosides or calcium antagonists.
  • Use in Pregnancy: Should be used during pregnancy only if the potential benefit justifies the risk to the fetus
  • Use in Nursing Mothers: Consideration should be given to discontinuing nursing or discontinuing the drug, taking into account the importance of the drug to the mother
  • Precautions: Monitor for hyperuricemia or acute gout. Watch for signs or symptoms of fluid and electrolyte imbalance. Withdrawal of therapy should be gradual over about 2 weeks.
  • Overdose Effects: Signs of overdose may include bradycardia, hypotension, lethargy, delirium, coma, convulsions, respiratory arrest, congestive heart failure, bronchospasm, and hypoglycemia.
  • Drug Interactions:
    • Potentiation with other antihypertensive agents
    • Avoid combining with other beta-blocking agents
    • Monitor closely when used with catecholamine-depleting drugs, clonidine, myocardial depressants, AV conduction inhibitors, digitalis glycosides or calcium antagonists
  • Maternal Use Precautions:
    • Consideration should be given to discontinuing nursing or discontinuing the drug, taking into account the importance of the drug to the mother
  • Dosage & Administration Guidance:
    • Antihypertensive therapy may be initiated with the lowest dose of this combination
    • Subsequent titration may be carried out with this combination up to the maximum recommended dose as appropriate

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