Cortiflu 0.05% (Ophthalmic Emulsion)

5 ml drop: ৳ 180.00

Medicine Details

Category Details
Generic Difluprednate
Company Navana pharmaceuticals ltd

Indications

  • Treatment of inflammation and pain associated with ocular surgery
  • Treatment of uveitis
  • Treatment of pseudophakic cystoid macular edema (CME)
  • Treatment of ocular surface diseases like blepharitis and corneal inflammation

Pharmacology

  • Corticosteroids inhibiting the inflammatory response
  • Delay or slow healing
  • Inhibition of edema and fibrin deposition
  • Inhibition of capillary dilation and leukocyte migration
  • Inhibition of scar formation associated with inflammation
  • Induction of phospholipase A2 inhibitory proteins
  • Control of biosynthesis of inflammation mediators
  • Structural similarity to other corticosteroids

Dosage & Administration

  • Instill 1 drop into the conjunctival sac of the affected eye 4 times daily post-surgery
  • Continuing throughout the first 2 weeks of the post-operative period
  • Subsequent taper based on the response
  • Different dosage for endogenous anterior uveitis, blepharitis, and pseudophakic cystoid macular edema

Interaction

  • No specific drug interaction studies conducted

Contraindications

  • Contraindicated in active viral diseases of the cornea and conjunctiva
  • Contraindicated in mycobacterial infection of the eye
  • Contraindicated in fungal diseases of ocular structures

Side Effects

  • Elevated intraocular pressure
  • Visual acuity and field defects
  • Posterior subcapsular cataract formation
  • Secondary ocular infection from pathogens including herpes simplex
  • Perforation of the globe
  • Various ocular adverse reactions associated with Cortiflu

Pregnancy & Lactation

  • Category C for pregnancy
  • Embryotoxic and teratogenic effects in animal studies
  • Potential risk to the embryo or fetus
  • Unknown passage into breast milk

Precautions & Warnings

  • Prolonged use may result in glaucoma and cataract formation
  • Monitoring of intraocular pressure if used for 10 days or longer
  • Caution required in patients with a history of herpes simplex
  • Risk of fungal infections
  • Precaution to avoid dropper tip contamination

Use in Special Populations

  • Pediatric use for inflammation following cataract surgery
  • Similar safety profile observed in pediatric patients
  • No significant differences in safety or effectiveness between elderly and younger patients

Overdose Effects

  • Overdosage not causing acute problems
  • Recommendation to drink fluids if accidentally ingested

Therapeutic Class

  • Ophthalmic steroid preparations

Storage Conditions

  • Room temperature storage
  • Protection from light and freezing
  • Avoid use more than 1 month after first opening

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