Voxamin XR 150 mg (Capsule (Extended Release))
Unit Price: ৳ 50.00 (3 x 6: ৳ 900.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluvoxamine maleate |
| Company | Renata limited |
| Also available as |
Indications
- Obsessive-Compulsive Disorder
- Depressive illness
- Panic Disorder
- Eating Disorders
- Chronic Tension Headache
Pharmacology
- Inhibition of CNS neuronal uptake of serotonin
- Enhancement of actions of serotonin on 5HT1A autoreceptors
- Affinity for binding to σ1 receptors
Dosage & Administration
- Recommended starting dose for adults: 50 mg
- Maximum therapeutic benefit not to exceed 300 mg per day
- Pediatric starting dose (ages 8-17 years): 25 mg
- Maximum dose in children up to age 11: 200 mg/day
- Elderly or Hepatically Impaired Patients: Adjusted initial dose and subsequent titration
Interaction
- Inhibition of cytochrome P450 isoenzymes (CYP1A2, CYP2C9, CYP3A4, CYP2C19)
- Elevated carbamazepine levels and symptoms of toxicity with coadministration
- Rare reports of weakness, hyperreflexia, and incoordination with SSRI and sumatriptan use
- Increased tacrine C max and AUC with coadministration
- Significantly increased plasma TCA levels with coadministration
- Severe vomiting with tryptophan coadministration
- Bradycardia with diltiazem coadministration
- Dose reduction and cautious titration with propranolol or metoprolol coadministration
Contraindications
- Coadministration of tizanidine, thioridazine, alosetron, pimozide
- Serotonin Syndrome and MAOIs
- Avoid use with linezolid or intravenous methylene blue within 14 days
Side Effects
- Nausea
- Somnolence
- Insomnia
- Asthenia
- Nervousness
- Dyspepsia
- Abnormal ejaculation
- Sweating
- Anorexia
- Tremor
- Vomiting
- Anorgasmia
- Decreased libido
- Dry mouth
- Rhinitis
- Taste perversion
- Urinary frequency
- Agitation
- Depression
- Dysmenorrhea
- Flatulence
- Hyperkinesia
- Rash
Pregnancy & Lactation
- Consider potential risks and benefits in treating a pregnant woman
- Infants exposed to SSRIs late in pregnancy may develop complications
- Secreted in human breast milk
Precautions & Warnings
- Use with caution in patients with a history of mania, seizures, suicide, concomitant ECT, cardiac disease, diabetes mellitus, angle-closure glaucoma, bleeding disorders, hepatic and renal impairment
- May impair performance of skilled tasks (driving)
Therapeutic Class
- SSRIs & related anti-depressant drugs
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children