Oxat 10 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paroxetine hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Major Depressive Disorder
- Obsessive Compulsive Disorder
- Panic Disorder
- Social Anxiety Disorder
- Generalized Anxiety Disorder
- Posttraumatic Stress Disorder
Pharmacology
- Potentiation of serotonergic activity
- Inhibition of neuronal reuptake of serotonin
- Blockage of serotonin uptake into human platelets
- Selective inhibitor of neuronal serotonin reuptake
- Little affinity for muscarinic, alpha1, alpha2, beta adrenergic, dopamine (D2), 5-HT1, 5 HT2, and histamine (H1)-receptors
Dosage & Administration
- Usual initial dosage of 20 mg/day for Major Depressive Disorder
- Maintenance therapy at doses averaging about 30 mg
- Usual initial dosage of 40 mg/day for Obsessive Compulsive Disorder
- Maintenance therapy with periodic reassessment
- Usual initial dosage of 40 mg/day for Panic Disorder
- Maximum dosage of 60 mg/day
- Usual initial dosage of 20 mg/day for Social Anxiety Disorder
- Usual initial dosage of 20 mg/day for Generalized Anxiety Disorder
- Usual initial dosage of 20 mg/day for Posttraumatic Stress Disorder
Interaction
- Absorption and pharmacokinetics not affected by food or antacids
- Potential interaction between Oxat and Tryptophan
- Effects on drug metabolizing enzyme inducers/inhibitors
- Advice against concomitant use of Oxat and alcohol in depressed patients
- Limited effect on sedation and drowsiness when combined with certain drugs
- Potential interaction with MAO inhibitors, lithium, phenytoin/anticonvulsants, and warfarin
Contraindications
- Concomitant use with MAOIs or thioridazine
- Hypersensitivity to Paroxetine
Side Effects
- Asthenia
- Sweating
- Nausea
- Decreased appetite
- Somnolence
- Dizziness
- Insomnia
- Tremor
- Nervousness
- Ejaculatory disturbance
- Dry mouth
- Constipation
- Impotence
- Abnormal ejaculation
- Female genital disorders
Pregnancy & Lactation
- Use during pregnancy if potential benefit justifies potential risk
- Caution during nursing as Paroxetine is secreted in human milk
Precautions & Warnings
- Caution when treating patients with cardiac conditions
- Use with caution in patients with epilepsy
- Discontinuation advice for GAD and PTSD clinical trials
- Recommended initial dosage of 10 mg/day for elderly patients and those with severe renal or hepatic impairment
Use in Special Populations
- Recommended initial dose of 10 mg/day for elderly, debilitated, and severe renal or hepatic impairment
Therapeutic Class
- SSRIs & related anti-depressant drugs
Storage Conditions
- Store at a cool and dry place
- Protect from light and moisture