Seroprex 100 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Quetiapine fumarate
Company Square pharmaceuticals plc
Also available as
Seroprex 25 mg tablet

Indications

  • Treatment of acute and chronic psychoses
  • Treatment of schizophrenia
  • Treatment of manic episodes in bipolar disorder
  • Treatment of depressive episodes in bipolar disorder
  • Maintenance treatment of bipolar I disorder

Pharmacology

  • Atypical psychotropic agent
  • Belongs to dibenzothiazepine derivatives
  • Antagonist at multiple neurotransmitter receptors (serotonin 5HT1A, 5HT2, dopamine D1, D2, histamine H1, adrenergic α1, α2)
  • No appreciable affinity at cholinergic muscarinic and benzodiazepine receptors

Dosage & Administration

  • Administered twice daily for acute and chronic psychoses
  • Administered twice daily for manic episodes associated with bipolar disorder
  • Administered once daily at bedtime for depressive episodes associated with bipolar disorder
  • Usual effective dose range of 300-450 mg/day for acute and chronic psychoses
  • Usual effective dose range of 400-800 mg/day for manic episodes associated with bipolar disorder
  • Usual dose of 300 mg/day for depressive episodes associated with bipolar disorder
  • Maintenance dose of 400-800 mg/day for bipolar I disorder in combination with mood stabilizers

Interaction

  • Caution with medicines known to cause electrolyte imbalance
  • Caution with medicines known to increase QT interval
  • Co-administration with thioridazine or carbamazepine increases clearance
  • Co-administration with phenytoin increases clearance

Contraindications

  • Hypersensitivity to Quetiapine

Side Effects

  • Somnolence
  • Dizziness
  • Dry mouth
  • Withdrawal symptoms
  • Elevations in serum triglyceride levels
  • Elevations in total cholesterol (predominantly LDL cholesterol)
  • Decreases in HDL cholesterol
  • Weight gain
  • Decreased haemoglobin
  • Extrapyramidal symptoms

Pregnancy & Lactation

  • Safety and efficacy not established in human pregnancy
  • Use during pregnancy only if benefits justify potential risks
  • Avoid breastfeeding while taking Quetiapine

Precautions & Warnings

  • Increased risk of suicidal thoughts
  • Caution in patients with known cardiovascular disease
  • Caution in patients with cerebrovascular disease
  • Caution in patients predisposed to hypotension
  • Caution when treating patients with a history of seizures
  • Consider dose reduction if signs of tardive dyskinesia appear
  • Discontinue if Neuroleptic Malignant Syndrome is suspected
  • Exercise caution in patients with cardiovascular disease or family history of QT prolongation
  • Monitor for severe neutropenia
  • Monitor for increases in blood glucose and hyperglycemia
  • Avoid use in children and adolescents below 18 years of age

Use in Special Populations

  • Use with caution in the elderly

Overdose Effects

  • Survival reported in acute overdoses up to 30 grams
  • No specific antidote
  • Consider multiple drug involvement
  • Intensive care procedures recommended

Therapeutic Class

  • Atypical neuroleptic drugs

Storage Conditions

  • Keep out of the sight and reach of children
  • Do not use after expiry date
  • Store in a cool and dry place away from light

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