Ticstop 12.5 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tetrabenazine |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of chorea associated with Huntington's disease
Pharmacology
- Acts as a vesicular monoamine transporter-2 (VMAT-2) inhibitor
- Formerly used as an antipsychotic
- Primarily used in the symptomatic treatment of various hyperkinetic disorders
Dosage & Administration
- Can be taken with or without food
- Requires careful weekly titration for dose individualization
- Starting dose: 12.5 mg daily for the 1st week
- Maximum daily dose in extensive and intermediate metabolizers: 100 mg
- Maximum daily dose in poor metabolizers: 50 mg
- Safety and effectiveness in pediatric patients not established
- Pharmacokinetics not formally studied in geriatric subjects
Interaction
- May require dose reduction when used with strong CYP2D6 inhibitors
- Reserpine and Ticstop should not be used concomitantly
- No interaction with food
Contraindications
- Actively suicidal, untreated or undertreated depression, hepatic impairment
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or reserpine
- Concurrent use of deutetrabenazine or valbenazine
Side Effects
- Common adverse reactions: Sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety, nausea
- Rare adverse reactions: Suicidal thoughts, neuroleptic malignant syndrome, pneumonia
Pregnancy & Lactation
- No adequate data on developmental risk in pregnant women
- No data on the presence of tetrabenazine or its metabolites in human milk
Precautions & Warnings
- Benefit and potential adverse effects should be periodically re-evaluated
- Maximum daily dose should not exceed 50 mg/day
- Maximum single dose should not exceed 25 mg if administered with strong CYP2D6 inhibitor
- In case of Neuroleptic Malignant Syndrome, treatment should be discontinued
- The treatment may impair patient's ability to drive or operate complex machinery
- Not recommended in combination with drugs that prolong QTc
Overdose Effects
- May include drowsiness, sweating, hypothermia
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Store in a cool & dry place
- Protect from light & moisture
- Keep out of reach of children