Tems Plus 80 mg+12.5 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Telmisartan hydrochlorothiazide
Company Eskayef pharmaceuticals ltd
Also available as
Tems plus 40 mg tablet

Indications

  • Treatment of hypertension
  • Lowering blood pressure
  • Reduction of cardiovascular risk
  • Use alone or with other antihypertensive agents

Pharmacology

  • Telmisartan blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Hydrochlorothiazide affects renal tubular mechanisms of electrolyte reabsorption
  • Telmisartan action independent of pathways for angiotensin II synthesis
  • Hydrochlorothiazide diuretic action reduces plasma volume
  • Mechanism of antihypertensive effect of thiazides not fully understood

Dosage & Administration

  • Initial dosage: Telmisartan monotherapy 80 mg or Hydrochlorothiazide 25 mg once daily
  • Possible titration to Telmisartan and Hydrochlorothiazide 160 mg/25 mg after 2 to 4 weeks
  • May be administered with other antihypertensive drugs

Interaction

  • Caution with aliskiren, digoxin, lithium, and other high blood pressure medications
  • Potential interference with certain laboratory tests

Contraindications

  • Contraindicated in patients with known hypersensitivity to ingredients
  • Do not co-administer with aliskiren in diabetic patients

Side Effects

  • Common: dizziness, drowsiness, back pain, nausea, diarrhea
  • Other adverse events: allergy, fever, chest pain, insomnia, elevated liver enzymes
  • Additional reported adverse events: weakness, gastric irritation, photosensitivity

Pregnancy & Lactation

  • Pregnancy Category D with potential fetal and neonatal adverse effects
  • Potential excretion in human milk with thiazides
  • Consideration for discontinuation during pregnancy or nursing

Precautions & Warnings

  • Medical history considerations: kidney disease, liver disease, dehydration, gout, lupus
  • Potential impact on blood sugar and body potassium levels
  • Dizziness warning and caution for activities requiring alertness
  • Monitoring and fluid intake recommendations

Use in Special Populations

  • Pediatric use not established
  • Caution in dose selection for elderly patients
  • Close medical supervision for patients with hepatic impairment
  • Recommendation against use in severe renal impairment

Overdose Effects

  • Manifestations: hypertension, dizziness, electrolyte imbalance, dehydration
  • Telmisartan not removed by hemodialysis
  • Degree of hydrochlorothiazide removal by hemodialysis not established

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Keep in a cool and dry place
  • Protect from light
  • Keep out of the reach of children

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