Pregaba ER 82.5 mg (Tablet (Extended Release))
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It binds with high affinity to the alpha2-delta site in central nervous system tissues, resulting in anti-nociceptive and antiseizure effects.
Dosage
- Maximum recommended dose for diabetic peripheral neuropathy (DPN): 300 mg/day
- Maximum recommended dose for postherpetic neuralgia (PHN): 300 mg/day
- Recommended dose for fibromyalgia: 300 to 450 mg/day
- Recommended dose for spinal cord injury: 150 to 600 mg/day
Administration
- Route of administration: Oral
- Pregabalin CR tablet administration: After an evening meal, swallowed whole and should not be split, crushed or chewed
Interaction
- Drug interaction with medication: Unlikely to be involved in significant pharmacokinetic drug interactions
Contraindications
Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components
Side Effects
- Most common side effects in adults:dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
- Most common side effects in pediatric patients:increased weight, increased appetite
Pregnancy & Lactation
Not recommended during treatment due to potential risk to the fetus. Small amounts of pregabalin detected in the milk of lactating women.
Precautions & Warnings
- Angioedema can occur and may be associated with life-threatening respiratory compromise
- Discontinue immediately in case of hypersensitivity reactions
- Increase in the risk of suicidal thoughts or behavior
Use in Special Populations
Safety and effectiveness in pediatric patients have not been established
Overdose Effects
Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
Keep in a cool & dry place (below 30°C), protected from light & moisture
Chemical Structure
- Molecular Formula: C₈H₁₇NO₂
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg
Common Questions
- What is Pregaba ER 82.5 mg XR Tablet? It is an anticonvulsant and is considered to be the first-line treatment for neurotic pain, shingles, seizures, and fibromyalgia.
- How long do I need to use Pregaba ER 82.5 mg XR Tablet before I see improvement in my condition? It should be taken until improvement is seen.
- At what frequency do I need to use Pregaba ER 82.5 mg XR Tablet? As prescribed by the doctor.
- Should I use Pregaba ER 82.5 mg XR Tablet empty stomach, before food or after food? After food in the prescribed dosage.
- What are the instructions for the storage and disposal of Pregaba ER 82.5 mg XR Tablet? Keep in a cool dry place and in its original packaging. Keep out of reach of children and pets.
- Does Pregaba ER 82.5 mg XR Tablet work in the same way for each disease? No, it works differently for different diseases.