Pregaba ER 330 mg (Tablet (Extended Release))

Unit Price: ৳ 45.00 (2 x 10: ৳ 900.00)
Strip Price: ৳ 450.00

Medicine Details

Category Details
Generic Pregabalin
Company Opsonin pharma ltd
Also available as
Pregaba 50 mg capsule Pregaba 75 mg capsule Pregaba 150 mg capsule Pregaba 25 mg capsule Pregaba 100 mg capsule Pregaba er 825 mg tablet Pregaba er 165 mg tablet

Indications

  • Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Postherpetic neuralgia (PHN)
  • Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
  • Fibromyalgia
  • Neuropathic pain associated with spinal cord injury

Pharmacology

Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), binds with high affinity to the alpha2-delta site in central nervous system tissues

Dosage

  • Maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 ml/min
  • Start dosing at 50 mg three times a day (150 mg/day) and increase to 300 mg/day within 1 week based on efficacy and tolerability
  • Begin dosing of Pregabalin CR capsule at 165 mg once daily and increase to 330 mg once daily within 1 week based on individual patient response and tolerability
  • Recommended dose of Pregabalin for postherpetic neuralgia is 75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day)
  • Start dosing Pregabalin CR at 165 mg once daily and increase to 330 mg once daily within 1 week based on individual patient response
  • Recommended dose for management of fibromyalgia is 300 to 450 mg/day
  • Recommended dose range of Pregabalin for neuropathic pain associated with spinal cord injury is 150 to 600 mg/day

Administration

  • Route of administration: Oral route, can be taken with or without food, Pregabalin CR tablet should be administered after an evening meal, should be swallowed whole and should not be split, crushed or chewed, if patients miss taking their dose of Pregabalin CR after an evening meal, then they should take their usual dose of Pregabalin CR prior to bedtime following a snack, if they miss taking the dose of Pregabalin CR prior to bedtime, then they should take their usual dose of Pregabalin CR following a morning meal, when discontinuing both Pregabalin and Pregabalin CR, it should be gradually tapered over a minimum of 1 week

Interaction

  • Drug interaction with medication: Unlikely to be involved in significant pharmacokinetic drug interactions
  • Drug interaction with food and others: Not applicable

Contraindications

Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

  • Dizziness
  • Somnolence
  • Dry mouth
  • Edema
  • Blurred vision
  • Weight gain
  • Difficulty with concentration/attention (thinking abnormal)
  • Increased weight and increased appetite in pediatric patients for the treatment of partial onset seizures

Pregnancy & Lactation

  • Pregnancy: No adequate and well-controlled studies in pregnant women, potential risk to fetus
  • Lactation: Small amounts have been detected in the milk of lactating women, breastfeeding not recommended due to potential risk of tumorigenicity

Precautions & Warnings

  • Angioedema: May occur and may be associated with life threatening respiratory compromise requiring emergency treatment
  • Hypersensitivity reactions: Discontinue immediately if occur
  • Suicidal thoughts or behavior: Increased risk with antiepileptic drugs including Pregaba ER
  • Respiratory depression: May occur when used with concomitant CNS depressants or in the setting of underlying respiratory impairment
  • Dizziness and somnolence: May impair patient's ability to drive or operate machinery
  • Seizure frequency: Increased if rapidly discontinued, should be withdrawn gradually over a minimum of 1 week
  • Peripheral edema: May cause, caution should be exercised when coadministering with thiazolidinedione antidiabetic agents

Use in Special Populations

  • Children and adolescents: Safety and effectiveness not established for various conditions
  • Pediatric patients: Safety and effectiveness of Pregaba ER extended-release tablet not established

Overdose Effects

Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

Storage Conditions

Keep in a cool & dry place (below 30°C), protected from light & moisture, keep out of the reach of children

Chemical Structure

  • Molecular Formula: C8H17NO2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg

Common Questions

  • What is Pregaba ER 330 mg XR Tablet?
  • How long do I need to use Pregaba ER 330 mg XR Tablet before I see improvement in my condition?
  • At what frequency do I need to use Pregaba ER 330 mg XR Tablet?
  • Should I use Pregaba ER 330 mg XR Tablet empty stomach, before food or after food?
  • Instructions for the storage and disposal of Pregaba ER 330 mg XR Tablet
  • Does Pregaba ER 330 mg XR Tablet work in the same way for each disease?
  • How long do I need to take Pregaba ER 330 mg XR Tablet?
  • Is it necessary to continue taking Pregaba ER 330 mg XR Tablet even if I feel fine?
  • Can I take Diazepam and Pregaba ER 330 mg XR Tablet together?
  • Can the use of Pregaba ER 330 mg XR Tablet cause weight gain?
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