Tolcid 200 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Albion laboratories limited |
Indications
- Relief of migraine headache pain
- Analgesic for post-operative pain
- Analgesic for fever
Pharmacology
- Belongs to fenamate group
- Inhibitor of cyclooxygenase enzyme
- Inhibits synthesis of thromboxane (TX) B2
- Inhibits synthesis of prostaglandin (PG) E2
- Direct antagonistic action on prostaglandin receptors
- Readily absorbed from GI tract
- Peak plasma concentration in 60-90 min
- Bioavailability of 85%
- Metabolized in the liver
- Excreted in urine and feces
Dosage & Administration
- Adult dosage for acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
- Adult dosage for mild to moderate pain: 100-200 mg tid
- Dose adjustments needed for renal impairment
- Avoid in severe renal impairment
- Pediatric dosage regimen not established
- Should be taken with food
- Water intake during or immediately after meals
Interaction
- Rate of absorption affected by Metoclopramide and Magnesium hydroxide
- Rate of absorption decreased with Aluminium hydroxide
- Increased risk of bleeding with anticoagulants and other NSAIDs
- Decreased antihypertensive response to loop diuretics, B-blockers, and ACE Inhibitors
- Co-administration increases plasma concentration of Lithium, Methotrexate, and cardiac glycosides
- Increases risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
Contraindications
- Active gastrointestinal bleeding
- Active gastrointestinal ulceration
- History of gastrointestinal bleeding related to previous NSAID therapy
- Severe heart failure
Side Effects
- Rare alveolitis
- Hepatic damage
- Pancreatitis
- Pulmonary eosinophilia
- Stevens-Johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastrointestinal bleeding
- Gastrointestinal discomfort
- Hallucination
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Raised blood pressure
Pregnancy & Lactation
- Not recommended during pregnancy unless essential
- Avoid during the third trimester of pregnancy
- NSAIDs can appear in breast milk in very low concentrations
- Avoid when breastfeeding if possible
Precautions & Warnings
- Needed for patients with asthma bronchospasm
- Bleeding disorders
- Cardiovascular diseases
- Peptic ulceration
- Hypertension
- Liver infection
- Cardiac or renal function impairment
- Elderly patients
- Increase water intake or dose reduction to reduce dysuria
Overdose Effects
- Headache
- Nausea
- Vomiting
- Epigastric pain
- Gastrointestinal bleeding
- Diarrhea
- Excitation
- Coma
- Drowsiness
- Dizziness
- Tinnitus
- Fainting
- Convulsions
- Possible acute renal failure and liver damage
- Symptomatic treatment required
Therapeutic Class
- Used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Other drugs for migraine
Storage Conditions
- Store in a cool and dry place
- Away from light
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C14H12ClNO2
Common Questions about Tolcid 200 mg Tablet
- Used for the treatment of acute migraine attacks and mild to moderate pain
- Should be taken with food or milk to avoid an upset stomach
- Can cause serious complications like stomach bleeding and kidney problems if taken for a long time
- Can raise the risk of blood clots, heart attack, or stroke
- Should be avoided if pregnant, planning to conceive, or breastfeeding
- Inform doctor if diagnosed with kidney or liver problems