Tolfamic 200 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Tolfenamic acid
Company Pristine pharmaceuticals ltd

Title

Tolfamic 200 mg Tablet

Categories

  • Pain Relief
  • NSAIDs
  • Migraine Relief
  • Analgesic
  • Fever Reducer

Description

Tolfenic acid is a potent inhibitor of cyclooxygenase enzyme and is used for relieving the pain of migraine headache, post-operative pain, and fever. It is readily absorbed from the GI tract and has a bioavailability of 85%. It should be taken with food and water during or immediately after meals. This medicine is contraindicated in cases of active gastrointestinal bleeding, ulceration, severe heart failure and during the third trimester of pregnancy. It should be used with precaution in patients with asthma, cardiovascular diseases, peptic ulceration, hypertension, and liver or renal impairment.

Dosage

  • Acute migraine attacks: 200 mg when symptoms appear may be repeated once after 1-2 hour
  • Mild to moderate pain: 100-200 mg tid

Pharmacology

  • Chemical Structure: C14H12ClNO2
  • Action: Inhibits the synthesis of inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2
  • Pharmacokinetics:
    • Absorption: Readily absorbed from GI tract
    • Peak Plasma Concentration: 60-90 minutes
    • Bioavailability: 85%
    • Distribution: Protein-binding: 99%
    • Plasma Half-Life: 2 hours
    • Metabolism: Metabolised in the liver
    • Excretion: Excreted in urine (90%) and feces

Indications

  • Relieves pain of migraine headache
  • Treats post-operative pain and fever

Interaction

  • Increases Absorption with:
    • Metoclopramide
    • Magnesium hydroxide
  • Decreases Absorption with:
    • Aluminium hydroxide
  • Risks:
    • Bleeding with anticoagulants and other NSAIDs
    • Decreased antihypertensive response to loop diuretics, B-blockers and ACE Inhibitors
    • Increased plasma concentration of Lithium Methotrexate and cardiac glycosides
  • Increases Risk of Nephrotoxicity with:
    • ACE inhibitors
    • Ciclosporin
    • Tacrolimus
    • Diuretics

Contraindications

  • Active gastrointestinal bleeding
  • Gastrointestinal ulceration
  • Severe heart failure
  • History of gastrointestinal bleeding related to previous NSAID therapy
  • History of gastrointestinal haemorrhage
  • History of gastrointestinal perforation related to previous NSAID therapy
  • History of recurrent gastrointestinal ulceration

Side Effects

  • Alveolitis
  • Hepatic damage
  • Pancreatitis
  • Pulmonary eosinophilia
  • Stevens-Johnson syndrome
  • Angioedema
  • Blood disorder
  • Depression
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dysuria
  • Euphoria
  • Gastrointestinal bleeding
  • Gastrointestinal discomfort
  • Hallucination
  • Insomnia
  • Malaise
  • Nausea
  • Hearing disturbances
  • Rash
  • Visual disturbances
  • Vertigo
  • Raised blood pressure

Pregnancy & Lactation

  • Pregnancy: Not recommended unless essential
  • Lactation: NSAIDs can appear in breast milk in very low concentrations, so preferably avoided

Precautions & Warnings

  • Patients with asthma
  • Patients with bleeding disorders
  • Patients with cardiovascular diseases
  • Patients with peptic ulceration
  • Patients with hypertension
  • Patients with liver infection
  • Patients with cardiac or renal function impairment
  • Elderly patients

Overdose Effects

  • Symptoms:
    • Headache
    • Nausea
    • Vomiting
    • Epigastric pain
    • Gastrointestinal bleeding
    • Diarrhea
    • Excitation
    • Coma
    • Drowsiness
    • Dizziness
    • Tinnitus
    • Fainting
    • Convulsions
  • Possible Complications:
    • Acute renal failure
    • Liver damage

Therapeutic Class

  • Rheumatoid Arthritis
  • NSAIDs
  • Migraine Drugs

Storage Conditions

Store in a cool and dry place, away from light. Keep out of the reach of children.

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