Sitafit 50 mg+500 mg (Tablet)

Unit Price: ৳ 18.00 (3 x 10: ৳ 540.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Team pharmaceuticals ltd

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Not indicated for type 1 diabetes or diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis

Pharmacology

  • Combines sitagliptin and metformin for glycemic control in type 2 diabetes
  • Sitagliptin is a DPP-4 inhibitor
  • Mechanism of action involves incretin hormone regulation
  • Metformin decreases hepatic glucose production and increases peripheral glucose uptake

Dosage & Administration

  • Individualized dosage based on current regimen and tolerability
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Initial combination therapy or maintenance should be individualized

Interaction

  • Use with caution with cationic drugs eliminated by renal tubular secretion
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction to the tablet or sitagliptin
  • Contradicted in patients undergoing radiologic studies with iodinated contrast materials

Side Effects

  • Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
  • Hypoglycemia reported with combination therapy
  • Nasopharyngitis reported with sitagliptin monotherapy
  • Common adverse reactions of metformin include diarrhea, nausea/vomiting, and headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Safety during pregnancy not well-known
  • Caution advised when administered to nursing women

Precautions & Warnings

  • Risk of lactic acidosis with metformin accumulation
  • Monitor thyroid-stimulating hormone levels and vitamin B12 serum levels
  • Do not use in patients with hepatic disease
  • Assess renal function before and during treatment
  • Monitor for evidence of ketoacidosis or lactic acidosis
  • Consider lower dose with insulin secretagogue or insulin co-administration
  • Reports of serious allergic and hypersensitivity reactions
  • No clinical studies establishing macrovascular risk reduction

Overdose Effects

  • Supportive measures in case of overdose
  • Sitagliptin is modestly dialyzable
  • Metformin is dialyzable with a clearance of up to 170 mL/min

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of reach of children
  • Do not use later than the date of expiry
  • To be dispensed only on prescription

Related Brands