Laxana 8 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Lubiprostone |
| Company | Renata limited |
| Also available as |
Indications
- Irritable Bowel Syndrome with Constipation (IBS-C)
- Chronic Idiopathic Constipation (CIC) in adults
- Opioid-Induced Constipation (OIC) in adult patients with chronic, non-cancer pain
Pharmacology
Lubiprostone is a locally-acting chloride-channel activator that increases intestinal secretion and motility, aiding the passage of stool and relieving symptoms associated with chronic idiopathic constipation.
Dosage & Administration
- Irritable Bowel Syndrome with Constipation: 8 mcg twice daily orally with food and water
- Dosage in patients with hepatic impairment:
- Moderately impaired hepatic function: 16 mcg twice daily
- Severely impaired hepatic function: 8 mcg twice daily
- Chronic Idiopathic Constipation and Opioid-induced Constipation: 24 mcg twice daily orally with food and water
Interaction
Possibility of a dose-dependent decrease in efficacy with diphenylheptane opioids
Contraindications
Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction
Side Effects
- Diarrhea
- Full or bloated feeling or pressure in the stomach
- Nausea
- Stomach pain
- Swelling of abdominal or stomach area
- Dyspnea
Pregnancy & Lactation
Pregnancy category C. The excretion of lubiprostone in human milk is not known. Caution should be exercised when administered to a nursing woman.
Precautions & Warnings
- Nausea: Patients taking Laxana may experience nausea. Concomitant administration of food may reduce symptoms
- Diarrhea: Should not be prescribed to patients with severe diarrhea
- Bowel Obstruction: Thorough evaluation to confirm the absence of an obstruction is recommended prior to initiating therapy with Laxana
Overdose Effects
Adverse reactions may include nausea, diarrhea, vomiting, dizziness, headache, abdominal pain, flushing/hot flash, retching, dyspnea, pallor, stomach discomfort, anorexia, asthenia, chest discomfort, dry mouth, hyperhidrosis, syncope
Therapeutic Class
Other laxative preparations
Storage Conditions
Store between 15-30° C