Renofix 20 mg (Tablet)
Unit Price: ৳ 200.00 (1 x 3: ৳ 600.00)
Strip Price: ৳ 600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Title and Categories
- Renofix
- Medicine
- Anemia Treatment
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD)
Description
- Orally administered HIF-PH inhibitor
- Promotes erythropoiesis
- Increases endogenous production of erythropoietin
- Improves iron regulation
- Overcomes EPO-suppressive effects of inflammation
- Downregulates hepcidin
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- Increases endogenous erythropoietin production
- Reduces hepcidin expression
- Improves iron availability
- Boosts hemoglobin levels
Dosage & Administration
- Orally administered three times per week
- Individualized dose for target Hb levels
- Starting dose based on patient weight
- Dose adjustment guidelines
- Method of administration: orally with or without food
Interaction
- Potential drug-drug interactions with phosphate binders
- Inhibitors may affect AUC and Cmax of Renofix
- Specific recommendations for combined use
Side Effects
- Common adverse reactions include hypertension
- Vascular access thrombosis
- Diarrhea
- Peripheral edema
- Hyperkalemia
- Nausea
Pregnancy & Lactation
- Contraindicated during pregnancy
- Contradicted during breast-feeding
Precautions & Warnings
- May initiate thrombotic vascular events
- Caution in patients with pre-existing risk factors
- Avoid in patients with history of seizures
- Avoid in serious signs and symptoms of infection
- Avoid in patients with liver disorder
- Not to be used in pregnant women
Use in Special Populations
- Not indicated in children
- Not recommended for patients with severe hepatic impairment
Overdose Effects
- Symptoms: increased heart rate, excessive increase in hemoglobin concentration
- Treatment: appropriate measures of dose reduction or interruption
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of the reach of children