Oroxat 20 mg (Tablet)
Unit Price: ৳ 175.00 (1 x 3: ৳ 525.00)
Strip Price: ৳ 525.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of symptomatic anemia associated with chronic kidney disease (CKD) in adult patients
Description
- First-in-class orally administered HIF-PH inhibitor
- Promotes erythropoiesis through increasing endogenous production of erythropoietin
- Improves iron regulation and overcomes the EPO-suppressive effects of inflammation on hemoglobin synthesis and red blood cell production by downregulating hepcidin
Pharmacology
- Orally bioavailable HIF-PH inhibitor
- Binds to and inhibits HIF-PH
- Prevents HIF breakdown and promotes HIF activity
- Increases endogenous erythropoietin production
- Reduces expression of the peptide hormone hepcidin
- Improves iron availability
- Boosts hemoglobin levels
Dosage & Administration
- Oral administration three times per week
- Individualized dose to achieve and maintain target Hb levels of 10 to 12 g/dL
- Usual starting dose for adults: 50 mg three times weekly
- Missed dose instructions provided
Interaction
- Potential drug-drug interactions with phosphate binders, gemfibrozil, probenecid, and certain substrates
Side Effects
- Common adverse reactions include hypertension, vascular access thrombosis, diarrhea, peripheral edema, hyperkalemia, and nausea
Pregnancy & Lactation
- Contraindicated during pregnancy and breastfeeding
Precautions & Warnings
- Caution in patients with pre-existing risk factors for thrombotic vascular events (TVEs)
- Caution in patients with a history of seizures
- Not to be administered in case of serious signs and symptoms of infection or liver disorder
- Not to be initiated in pregnant women
Use in Special Populations
- Not indicated in children
- Not recommended in patients with severe hepatic impairment
Overdose Effects
- Symptoms may include increased heart rate transient
- Treatment involves appropriate measures of dose reduction or interruption
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Store in a cool (below 30°C), dry place, away from light and moisture
- Keep out of the reach of children