Oroxat 50 mg (Tablet)
Unit Price: ৳ 285.00 (1 x 3: ৳ 855.00)
Strip Price: ৳ 855.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxadustat |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of adult patients
- Symptomatic anemia
- Chronic kidney disease (CKD)
Description
- Frst-in-class
- Orally administered
- HIF-PH inhibitor
- Erythropoiesis promotion
- Endogenous erythropoietin production
- Improved iron regulation
- EPO-suppressive efects inhibition
- Hepcidin downregulation
Pharmacology
- Orally bioavailable
- Hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI)
- EPO levels regulation
- Increased red blood cell count
- Iron metabolism regulation
Dosage & Administration
- Oral administration
- Dosing three times per week
- Individualized dosing
- Dose adjustment guidelines
- Starting dose based on patient weight
- Missed dose instructions
Interaction
- Drug-drug interaction potential
- Specific interactions with phosphate binders
- Interaction with gemfibrozil and probenecid
- Interaction with statins
Side Effects
- Hypertension
- Vascular access thrombosis
- Diarrhea
- Peripheral edema
- Hyperkalemia
- Nausea
Pregnancy & Lactation
- Contraindicated in pregnancy
- Contraindicated during breastfeeding
Precautions & Warnings
- Caution in use
- Thrombotic vascular events (TVEs) risk
- Seizure history caution
- Infection caution
- Liver disorder caution
Use in Special Populations
- Not indicated in children
- Not recommended in severe hepatic impairment
Overdose Effects
- Increased heart rate
- Hemoglobin concentration increase
- Dose reduction measures
- No dialysis removal
Therapeutic Class
- Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Cool and dry storage
- Protected from light and moisture
- Keep out of reach of children