Indaren-G 110 mcg+50 mcg (Inhalation Capsule)

Unit Price: ৳ 70.00 (3 x 10: ৳ 2,100.00)
Strip Price: ৳ 700.00

Medicine Details

Category Details
Generic Indacaterol glycopyrronium
Company Renata limited

Therapeutic Class

  • Combined bronchodilators

Indications

  • Long-term once-daily maintenance bronchodilator treatment
  • Airflow obstruction in patients with chronic obstructive pulmonary disease (COPD)
  • Chronic bronchitis
  • Emphysema

Composition

  • Indacaterol 110 mcg as Indacaterol Maleate INN (Micronized)
  • Glycopyrronium 50 mcg as Glycopyrronium Bromide BP (Micronized)

Pharmacology

  • Inhalation powder drug
  • Delivery of a combination of Glycopyrronium and Indacaterol by oral inhalation
  • Pharmacologic effects of beta2-adrenoceptor agonist drugs
  • Stimulation of intracellular adenyl cyclase
  • Increased cyclic AMP levels causing relaxation of bronchial smooth muscle

Dosage & Administration

  • For adults (18 years or older)
  • Oral inhalation only
  • Maintenance treatment of COPD: 1 inhalation once daily
  • Use at the same time every day, not more than 1 time every 24 hours
  • Geriatric use at the recommended dose
  • Not indicated for use in children and adolescents
  • Safe for patients with mild to moderate renal impairment
  • Safe for patients with mild to moderate hepatic impairment

Interaction

  • No specific interaction studies conducted for the combination
  • Concomitant use with β-adrenergic blockers, anticholinergics, or sympathomimetic agents not recommended
  • Caution required with concomitant use of hypokalemic treatment

Contraindications

  • Hypersensitivity to Glycopyrronium or Indacaterol
  • Severe hypersensitivity to milk proteins
  • Contraindicated in patients with asthma without use of a long-term asthma control medication

Side Effects

  • Cardiovascular effects
  • Ocular disorders
  • Urinary retention
  • Gastrointestinal disorders
  • Dry mouth
  • Cough
  • Immediate hypersensitivity reactions
  • Hypokalemia
  • Hyperglycemia
  • Headache
  • Nervousness
  • Insomnia
  • Muscle spasms
  • Fatigue
  • Malaise

Pregnancy & Lactation

  • Pregnancy category C
  • Use during pregnancy justified if expected benefit to the patient outweighs potential risk to the fetus
  • Consideration for use in breast-feeding women if expected benefit to the woman is greater than any possible risk to the infant

Precautions & Warnings

  • Increases the risk of serious asthma-related events
  • Not to be used in acutely deteriorating COPD or asthma
  • Use with caution in patients with cardiovascular disorders
  • Use with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, and ketoacidosis
  • Worsening of narrow-angle glaucoma may occur
  • Worsening of urinary retention may occur
  • Alert to hypokalemia and hyperglycemia

Overdose Effects

  • Information not available on clinically relevant overdosing
  • Overdose could lead to exaggerated effects of β2-adrenergic stimulants or induce anticholinergic effects
  • Supportive and symptomatic treatment indicated

Storage Conditions

  • Avoid storage in direct sunlight or heat
  • Store in a cool & dry place
  • Keep away from eyes
  • Keep all medicines out of reach of children

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