Levamdocal 2.5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Beximco pharmaceuticals ltd |
| Also available as | Levamdocal 125 mg tabletLevamdocal 5 mg tablet |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reduce risk of cardiovascular events
Pharmacology
- Dihydropyridine calcium antagonist
- Inhibits transmembrane influx of calcium ions
- Greater effect on vascular smooth muscle cells
- Pharmacologically active levamlodipine
- Tmax of 6-12 hours
- Bioavailability of 64-90%
- Metabolized by CYP3A4
- 60% eliminated in urine
Dosage & Administration
- Oral route of administration
- Usual initial dose of 2.5 mg once daily
- Maximum dose of 5 mg once daily
- Dosage adjustment for elderly and hepatically impaired patients
- Pediatric dosage of 1.25-2.5 mg once daily
Interaction
- CYP3A Inhibitors impact
- CYP3A Inducers impact
- Impact on Simvastatin
- Impact on Immunosuppressants
- Can be taken with or without food
- Avoid grapefruit products & natural licorice
Contraindications
- Contraindicated in patients with known sensitivity to amlodipine
Side Effects
- Common: difficulty in breathing, dizziness, reflex tachycardia, hypotension, abdominal pain, edema
- Rare: diarrhea, back pain, headache, fatigue, nausea
Pregnancy & Lactation
- Limited data on use in pregnant women
- No adverse effects on breastfed infants observed
Precautions & Warnings
- Risk of symptomatic hypotension
- Risk of increased angina or myocardial infarction
- Caution in patients with hepatic failure
Overdose Effects
- Excessive peripheral vasodilation
- Marked hypotension
- Possibly reflex tachycardia
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store in a cool & dry place
- Protect from light & moisture
- Keep out of reach of children