REMMO 40 mg/vial (IV Injection)

40 mg vial: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Beximco pharmaceuticals ltd
Also available as
Remmo 20 mg tablet Remmo 40 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole
  • 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Ensures greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax
  • Combines fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Better and more uniform drug absorption
  • Reduces esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug
  • Ensures rapid and uniform gastric emptying
  • Facilitates consistent and controlled pharmacological action
  • Reduces inter- and intra-subject variability in drug absorption and clinical response

Pharmacology

Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system

Dosage

  • Erosive esophagitis: 40 mg once daily for adults (≥18 years), 40 mg once daily for children & adolescents (12-18 years)
  • Maintenance of healing of erosive esophagitis: 20 mg once daily for adults (≥18 years), 20 mg once daily for children & adolescents (12-18 years)
  • Risk reduction in NSAID associated gastric ulcer: 20 mg once daily for adults (≥18 years) for 4-8 weeks
  • H. pylori eradication: 20 mg twice daily for adults (≥18 years) for 7 days, 20 mg twice daily for children & adolescents (12-18 years) for 7 days
  • Zollinger-Ellison syndrome and idiopathic hypersecretion: 40-80 mg twice daily for adults (≥18 years)

Administration

Tablets should be swallowed whole with liquid, not chewed or crushed. Can also be dispersed in half a glass of non-carbonated water and should be taken immediately or within 30 minutes. Rinse the glass with half a glass of water and drink. Pellets must not be chewed or crushed.

Interaction

Metabolized in the liver by CYP2C19 and CYP3A4. Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4. No clinically relevant interactions with drugs metabolized by these CYP enzymes are expected. Potential interference with CYP2C19. No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin. May interfere with the absorption of drugs where gastric pH is important. Co-administration with clarithromycin has led to increased plasma levels of REMMO and 14-hydroxyclarithromycin.

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

Manufacturer advises caution due to unknown presence in human breast milk

Precautions & Warnings

  • Use carefully with severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist and spine fracture, particularly when taken over a period of more than one year

Storage Conditions

Store in a cool & dry place below 25°C, protect from light. Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions

  • REMMO 40 mg/vial Injection:
    • What it is: Proton pump inhibitor used to treat GERD, ulcers, and other conditions related to excess stomach acid
    • Use: Relieves heartburn and GERD symptoms, aids in healing erosive esophagitis, and prevents its recurrence
    • Side Effects:
      • Headaches
      • Diarrhea
      • Nausea
      • Gas
      • Stomach pain
      • Constipation
      • Dry mouth
    • Pregnancy & Breastfeeding: No known side-effects but caution advised, consult a doctor
    • Time to Work: Usually starts to work within a few hours of taking it
    • Quick Tips:
      • Well-tolerated and provides relief for a long time
      • Avoid eating late at night or before bedtime
      • Inform your doctor if you experience watery diarrhea, fever, or persistent stomach pain
      • Long-term use can weaken bones and lead to mineral deficiencies
      • Consult your doctor immediately if you develop certain symptoms indicating a kidney problem

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