Lipitin 40 mg (Tablet)

Unit Price: ৳ 24.07 (1 x 10: ৳ 240.70)
Strip Price: ৳ 240.70

Medicine Details

Category Details
Generic Atorvastatin calcium
Company General pharmaceuticals ltd
Also available as
Lipitin 10 mg tablet Lipitin 20 mg tablet

Title

Lipitin 40 mg Tablet

Categories

  • Medicine
  • Cholesterol Management
  • Cardiovascular Health

Description

Lipitin is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases.

Dosage

Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily. Children (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks.

Indications

  • Reduce total cholesterol and LDL cholesterol in patients with familial hypercholesterolaemia
  • Reduce elevated cholesterol and triglycerides in patients with mixed dyslipidemia
  • Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia
  • Reduce cardiac ischaemic events in patients with coronary artery disease
  • Reduce total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with diabetes mellitus or renal transplantation

Mode of action

Selectively inhibits HMG-CoA reductase, lowering plasma cholesterol and lipoprotein levels by inhibiting cholesterol synthesis in the liver.

Absorption

Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.

Distribution

Mean volume of distribution of Atorvastatin is approximately 381 liters. Atorvastatin is 98% bound to plasma proteins.

Metabolism

Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.

Excretion

Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism.

Interaction

  • Increases myopathy risk:
    • Concurrent administration with cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
  • Antacid: Decreases plasma concentrations of atorvastatin by approximately 35%, but LDL-C reduction is not altered
  • Colestipol: Decreases plasma concentrations of atorvastatin by approximately 25%, but LDL-C reduction is greater
  • Digoxin: Steady-state plasma digoxin concentrations increased by approximately 20% when coadministered with atorvastatin
  • Erythromycin: Plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin
  • Oral contraceptives: Increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%
  • Warfarin: No clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment

Contraindications

  • Hypersensitivity to any component of this medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side effects

  • Frequent side effects:
    • Constipation
    • Flatulence
    • Dyspepsia
    • Abdominal pain
  • Other side effects:
    • Infection
    • Headache
    • Back pain
    • Rash
    • Asthenia
    • Arthralgia
    • Myalgia

Precautions warnings

  • Liver effects: Liver function tests should be performed before initiation of treatment and periodically thereafter; use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease.
  • Elderly use: Plasma concentrations are higher in healthy elderly subjects; greater degree of LDL-lowering compared to younger adults
  • Renal hepatic insufficiency: Does not influence plasma concentrations or LDL-C reduction; dose adjustment not necessary

Pregnancy lactation

  • Pregnancy: Contraindicated during pregnancy; safety not established; should be suspended for the duration of pregnancy
  • Lactation: Not known whether excreted in human milk; contraindicated during breastfeeding

Overdose effects

Specific treatment not available for atorvastatin overdose; symptomatically and supportive measures instituted, as required; liver function tests should be performed and serum CK levels monitored.

Commonly asked questions

  • Uses:
    • Avoid heart attacks
    • Treat conditions like Mixed Dyslipidemia and Hypertriglyceridemia
  • Administration: Take by mouth once daily, at the same time each day; can be taken with or without food
  • Side effects:
    • Cough
    • Muscle pain
    • Breathing difficulty
    • Running nose
  • Storage disposal instructions: Store at room temperature, away from heat and direct light; keep away from the reach of children and pets
  • Long term use: Considered safe for long term use if taken as directed by the doctor

Therapeutic class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage conditions

Keep in a dry place away from light and heat; keep out of the reach of children.

Chemical structure

  • Molecular formula: C33H35FN2O5
  • Chemical structure image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Related Brands