Endozol 100 mg (Capsule)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Danazol |
| Company | Drug international ltd |
Indications
- Endometriosis
- Benign breast disease
- Menorrhagia
- Gynecomastia
- Preoperative thinning of the endometrium before hysteroscopic endometrial ablation
Pharmacology
- Suppression of pituitary-ovarian axis
- Depression of preovulatory surge in FSH and LH
- Inhibition of ovarian steroidogenesis
- Binding to androgen, progesterone, and glucocorticoid receptors
- Increase in metabolic clearance rate of progesterone
- Suppression of ovarian function
- Correcting biochemical deficiency in hereditary angioedema
Dosage & Administration
- Usually given in up to 4 divided doses
- Treatment should start during menstruation in women of child-bearing potential
- 200-800 mg daily for endometriosis
- 100-200 mg daily for menorrhagia
- 100-400 mg daily for severe cyclical mastalgia
- 300 mg daily for benign breast cysts
- 400 mg daily for gynaecomastia
- 400 mg-800 mg daily for pre-operative thinning of endometrium
Interaction
- Increased insulin resistance with insulin
- Potential interaction with exogenous estrogens and/or progestogens
- Effect on plasma concentration of anticonvulsants, antihypertensives, cyclosporine, and migraine therapy
Contraindications
- Pregnancy and breast-feeding
- Impaired hepatic, renal, or cardiac function
- Porphyria
- Thromboembolic disease
- Androgen-dependent tumor
- Abnormal vaginal bleeding
- Hypersensitivity to danazol
Side Effects
- Nausea
- Dizziness
- Skin reactions
- Mood changes
- Changes in libido
- Fatigue
- Headache
- Menstrual disturbances
- Musculo-skeletal spasm
- Androgenic effects
- Metabolic changes
- Thrombotic events
- Leucopenia
- Thrombocytopenia
- Erythrocytosis
- Visual disturbances
Pregnancy & Lactation
- Risk of virilization of female fetus
- Not to be given to pregnant women
- Patients should not breast-feed
Precautions & Warnings
- Cardiac, hepatic or renal impairment
- Polycythaemia
- Epilepsy
- Diabetes mellitus
- Hypertension
- Migraine
- Lipoprotein disorder
- History of thrombosis or thromboembolic disease
- Signs of virilization
Therapeutic Class
- Drugs affecting (inhibiting) gonadotrophin
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children