Ferox 750 mg/15 ml (IV Injection or Infusion)

15 ml vial: ৳ 1,000.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Aci limited
Also available as
Ferox 500 mg injection Ferox 100 mg injection Ferox 1 gm injection

Indications

  • Treatment of iron deficiency anaemia in adult patients
  • Intolerance to oral iron or unsatisfactory response to oral iron
  • Non-dialysis dependent chronic kidney disease

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose
  • Carbohydrate polymer that releases iron

Dosage & Administration

  • Stepwise approach for determination and administration of iron dose(s)
  • Posology based on individual iron need, body weight, and haemoglobin (Hb) level
  • Calculation and administration of maximum individual iron dose(s)
  • Post-iron repletion assessments by the clinician

Interaction

  • Formal drug interaction studies not performed

Contraindications

  • Hypersensitivity to the active substance, Ferric Carboxymaltose or its excipients
  • Serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in iron utilisation

Side Effects

  • Infrequent, usually mild side effects
  • Nausea, headache, dizziness, hypertension, injection site reactions
  • Alanine aminotransferase increased, hypophosphataemia
  • Hypersensitivity, dysgeusia, tachycardia, hypotension, flushing, dyspnoea
  • Abdominal pain, constipation, diarrhea, pruritus, urticaria, rash, myalgia
  • Back pain, arthralgia, muscle spasms, pyrexia, fatigue, chest pain, oedema peripheral
  • Chills, aspartate aminotransferase increased, gamma glutamyl transferase increased

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Benefit/risk evaluation required before use during pregnancy
  • Unlikely risk to breast-fed child

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Monitor for signs and symptoms of hypersensitivity
  • Monitor for signs and symptoms of hypertension
  • Laboratory test alterations in iron and transferrin bound iron
  • Personnel and therapies immediately available for treatment of serious hypersensitivity reactions

Use in Special Populations

  • Haemodialysis-dependent chronic kidney disease patients
  • Single maximum daily injection dose of 200 mg iron should not be exceeded
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to accumulation of iron in storage sites
  • Monitor iron parameters such as serum ferritin and transferrin saturation
  • Consider the use of an iron chelator for treatment

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Cool and dry place (below 30°C), away from light
  • Do not freeze
  • Keep out of the reach of children

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