Betagest 100 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Labetalol hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Hypertension
- Hypertension in pregnancy
- Hypertension after stroke
- Hypertensive crisis
- Anaesthesia with hypotensive technique
Pharmacology
- Adrenergic receptor-blocking agent
- Selective alpha 1-adrenergic and nonselective beta-adrenergic receptor-blocking actions
- Decrease in blood pressure
- Peak plasma levels occurring 1 to 2 hours after oral administration
- Plasma half-life of about 6 to 8 hours
Dosage & Administration
- Recommended initial dosage of 100 mg twice daily for adults
- Maintenance dosage between 200 and 400 mg twice daily
- Higher dosage for severe hypertension
- Intravenous injection and infusion
- Specific dosages for various conditions like hypertension in pregnancy, following acute myocardial infarction, after stroke, and hypotensive anaesthesia
Interaction
- Enhanced hypotensive effects with halothane
- Care needed when used with Class I antiarrhythmic agents or calcium antagonists
- Reduced hypotensive effect when used with prostaglandin synthetase inhibitors
- Increased incidence of tremor with tricyclic antidepressants
- Increased bioavailability with cimetidine
Contraindications
- Hypersensitivity to the medicine
- Second or third degree heart block
- Uncontrolled heart failure
- Sick-sinus syndrome
- Cardiogenic shock
- Bronchial asthma or other obstructive lung disorders
Side Effects
- Postural hypotension
- Tiredness
- Weakness
- Headache
- Rashes
- Scalp tingling
- Difficulty in micturition
- Epigastric pain
- Nausea
- Vomiting
- Liver damage
Pregnancy & Lactation
- Teratogenic studies in rats and rabbits
- No reproducible evidence of fetal malformations
- Small amounts excreted in human milk
Precautions & Warnings
- Rare reports of severe hepatocellular injury
- Reversible hepatic injury
- Caution in patients with hepatic impairment
- Use with caution in patients with peripheral vascular disease
Overdose Effects
- Excessive hypotension
- Excessive bradycardia
- Gastric lavage or induced emesis for removal
- Administer atropine for excessive bradycardia
- Administer digitalis glycoside and diuretic for cardiac failure
- Administer vasopressors for hypotension
- Administer epinephrine for bronchospasm
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
Storage Conditions
- Cool & dry place
- Protected from light
- Keep out of reach of children