Metarin XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults with type 2 diabetes
- Combination therapy for adults with type 2 diabetes
- Combination therapy for children and adolescents with type 2 diabetes
Pharmacology
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose for adults: 500 mg twice a day
- Usual starting dose for children: 500 mg twice a day
- Max daily dose for adults: 2550 mg
- Max daily dose for children: 2000 mg
- Instructions for extended release tablet usage
Interaction
- No chronic interaction with Furosemide
- Enhances absorption of Nifedipine
- No effect on Cimetidine pharmacokinetics
- Potential interaction with cationic drugs
- Certain drugs may lead to loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk
- Use of insulin recommended during pregnancy
- Metformin excreted into breast milk
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Potential lactic acidosis
- Lowered vitamin B12 level
- Increased risk of hypoglycemia in combination with insulin
- Regular monitoring of renal function advised
- Caution in conditions causing dehydration or serious infections
Use in Special Populations
- Adjustment of metformin dosage in elderly subjects
- Careful follow-up of parameters in metformin-treated children
- Caution in prescribing to children aged 10-12 years
- Regular assessment of renal function
Overdose Effects
- No hypoglycemia seen at high doses
- Lactic acidosis a medical emergency
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children