Metarin XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Popular pharmaceuticals ltd
Also available as
Metarin 500 mg tablet Metarin 850 mg tablet Metarin xr 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy for adults with type 2 diabetes
  • Combination therapy for adults with type 2 diabetes
  • Combination therapy for children and adolescents with type 2 diabetes

Pharmacology

  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose for adults: 500 mg twice a day
  • Usual starting dose for children: 500 mg twice a day
  • Max daily dose for adults: 2550 mg
  • Max daily dose for children: 2000 mg
  • Instructions for extended release tablet usage

Interaction

  • No chronic interaction with Furosemide
  • Enhances absorption of Nifedipine
  • No effect on Cimetidine pharmacokinetics
  • Potential interaction with cationic drugs
  • Certain drugs may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated with increased risk
  • Use of insulin recommended during pregnancy
  • Metformin excreted into breast milk
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Potential lactic acidosis
  • Lowered vitamin B12 level
  • Increased risk of hypoglycemia in combination with insulin
  • Regular monitoring of renal function advised
  • Caution in conditions causing dehydration or serious infections

Use in Special Populations

  • Adjustment of metformin dosage in elderly subjects
  • Careful follow-up of parameters in metformin-treated children
  • Caution in prescribing to children aged 10-12 years
  • Regular assessment of renal function

Overdose Effects

  • No hypoglycemia seen at high doses
  • Lactic acidosis a medical emergency

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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