Metarin XR 1000 mg (Tablet (Extended Release))
Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Use in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Usual starting dose for adults and children
- Dosage increases in increments
- Recommended maximum daily doses
- Instructions for immediate release and extended release tablets
- Caution for renal impaired patient
Interaction
- No information available for Metarin XR and Furosemide interaction
- Effects on Nifedipine absorption
- Potential interaction with cationic drugs
- Drugs that produce hyperglycemia and may affect glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions affecting renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk associated with uncontrolled diabetes during pregnancy
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- Precaution and limited data for breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis and hypoglycemia
- Monitoring of renal function
- Discontinuation before surgery and clinical investigations
- Advice for conditions causing dehydration or serious infections
- Regular assessment of Vitamin B12 levels
- Caution for concomitant therapy with sulphonylurea
- Potential interaction with anticoagulants
- Dosage adjustment in elderly
- Caution in pediatric population
- Monitoring of renal function and GFR assessment
Use in Special Populations
- Adjustment of metformin dosage in elderly subjects
- Confirmation of type 2 diabetes mellitus diagnosis before treatment
- No effect on growth and puberty observed during studies
- Particular caution for children aged between 10 and 12 years
Overdose Effects
- No hypoglycemia seen with Metarin XR doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment method for lactic acidosis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protection from light & moisture
- Keep out of the reach of children